Bunias erucago L.: Glucosinolate Profile and In Vitro Biological Potential

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Ivica BlaževićIvana Generalić Mekinić

Abstract

Bunias erucago belongs to the Brassicaceae family, which represents a forgotten crop of the Euro-Mediterranean area. The aim of the present study was to determine the glucosinolate profile in different plant parts and biological properties (antioxidant, anticholinesterase, and cytotoxic activities) of the isolates containing glucosinolate breakdown products. The chemical profiles were determined by using HPLC-PDA-MS/MS of desulfoglucosinolates and GC-MS of glucosinolate degradation products. The analysis of B. erucago showed the presence of seven glucosinolates: gluconapin (1), glucoraphasatin (2), glucoraphenin (3), glucoerucin (4), glucoraphanin (5), glucotropaeolin (6), and glucosinalbin (7). The total glucosinolate content ranged from 7.0 to 14.6 µmol/g of dry weight, with the major glucosinolate glucosinalbin in all parts. The antioxidant activity of all volatile isolates was not notable. At a tested concentration of 227 μg/mL, flower hydro-distillate (FH) showed good AChE inhibition, i.e., 40.9%, while root hydro-distillate (RH) had good activity against BChE, i.e., 54.3%. FH showed the best activity against both tested human bladder cancer cell lines, i.e., against T24 after 72 h, which have IC50 of 16.0 μg/mL, and again...Continue Reading

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Citations

Aug 7, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Krešimir BaumannSrđanka Tomić
Aug 19, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sylvia MainaHo-Youn Kim
Nov 15, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marta Klimek-SzczykutowiczAgnieszka Szopa
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rurui LiXuechun Zhang
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marta Klimek-SzczykutowiczAgnieszka Szopa
Jan 6, 2022·Applied Microbiology and Biotechnology·Marta Klimek-SzczykutowiczAgnieszka Szopa

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