Buoyancy and drug release patterns of floating minitablets containing piretanide and atenolol as model drugs

Pharmaceutical Development and Technology
N RougeP Buri

Abstract

The purpose of this study was to evaluate factors for improving the in vitro buoyancy and the drug release characteristics of floating minitablets containing either piretanide or atenolol as model drugs. The buoyancy of the minitablets was achieved either by the swelling of the excipient or by incorporation of the gas-generating agent sodium bicarbonate. Resultant-weight kinetics were performed in order to evaluate the buoyancy. The release rate of the poorly soluble drug piretanide was enhanced by increasing its solubility or by promoting the erosion of the minitablets. For the sparingly soluble drug atenolol, the minitablets were coated with different ratio of insoluble polymer in order to diminish the release rate of this drug. The swelling of a hydrophilic excipient was not sufficient to obtain floating minitablets. The buoyancy of the minitablets containing either piretanide or atenolol was greatly improved by adding sodium bicarbonate as well as by a wet granulation. The most satisfactory improvement in the release rate of piretanide was achieved using a solid dispersion with povidone, thus increasing the drug solubility concomitantly with the increase of the minitablets' erosion. Regarding atenolol, minitablets containin...Continue Reading

Citations

Dec 16, 2005·AAPS PharmSciTech·Shweta AroraSanjula Baboota
Mar 2, 2006·Expert Opinion on Drug Delivery·Alexander StreubelRoland Bodmeier
Aug 27, 2015·Drug Development and Industrial Pharmacy·Veronika A EberleMaxim Puchkov
Jul 13, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yasunori SatoYasuhisa Fujibayashi
May 20, 2003·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Yasunori SatoHiromitsu Yamamoto

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