Abstract
The finding that i.v. lidocaine suppresses cardiac sympathetic nerve activity during 1 MAC halothane, but not during 2 MAC or 3 MAC halothane, suggests that the neurally mediated circulatory effects of i.v. local anesthetics may vary with background autonomic activity. This study aimed to compare the effects of i.v. lidocaine and bupivacaine on cardiac sympathetic nerve activity (CSNA) during normal and high levels of CSNA. Cats were anesthetized with halothane and allocated to three groups. In groups I-L and I-B, sympathetic hyperactivity was induced by electrical stimulation of the posterior hypothalamus. CSNA, heart rate and mean arterial pressure were then measured before and after administration of lidocaine 2 mg.kg BW-1 i.v. (Group I-L, n = 7) or bupivacaine 0.5 mg.kg BW-1 i.v. (Group I-B, n = 7) during 1% halothane anesthesia. In Group II (n = 7), following administration of bupivacaine 0.5 mg.kg BW-1 i.v., CSNA, sinus cycle length (SCL), and subintervals of atrioventricular conduction time (A-H, H-V, and H-S) at pacing were measured during 0.8%, 1.6% and 2.4% halothane anesthesia without sympathetic hyperactivity. Lidocaine suppressed CSNA hyperactivity and tachycardia significantly in Group I-L, but bupivacaine did not...Continue Reading
References
Dec 1, 1977·Anesthesiology·E J FoxB D King
Oct 1, 1979·Anesthesiology·G A Albright
Jan 1, 1991·Anesthesiology·C M Bernards, A A Artu
Oct 1, 1991·Anesthesia and Analgesia·L BertrixG Faucon
Oct 1, 1991·Journal of Cardiothoracic and Vascular Anesthesia·T J EbertJ P Kampine
Apr 1, 1990·Acta Anaesthesiologica Scandinavica·K NishikawaM Fujimori
Aug 1, 1990·Anesthesiology·J M BadgwellJ Kytta
Jul 1, 1986·British Journal of Anaesthesia·B G Covino
Jul 1, 1986·British Journal of Anaesthesia·S Reiz, S Nath
Feb 1, 1988·Anesthesia and Analgesia·R A Moller, B G Covino
Jul 1, 1986·Anesthesiology·G W Kasten
Aug 1, 1986·Anesthesiology·R A JohnsD E Longnecker
Dec 1, 1986·Anesthesia and Analgesia·S NathS Reiz
Feb 1, 1986·Anesthesia and Analgesia·J E Heavner
May 1, 1986·Anesthesia and Analgesia·R D ThomasD D Denson
Oct 1, 1985·Anesthesiology·H S Chadwick
Aug 1, 1970·Anesthesiology·R L Katz, J T Bigger
May 1, 1966·American Heart Journal·C H HockmanE C Hoff
Jun 1, 1984·Acta Anaesthesiologica Scandinavica·H YukiokaM Fujimori
May 1, 1983·The Journal of Clinical Investigation·B D MillerA L Mark
Jan 1, 1982·Anesthesia and Analgesia·R H de JongR A DeRosa
Sep 1, 1981·Anesthesiology·H Komai, B F Rusy
Feb 1, 1994·Acta Anaesthesiologica Scandinavica·K NishikawaM Fujimori
Jun 1, 1964·Circulation Research·J HANG K MOE
Nov 18, 1961·Nature·L MIHAILOVIC, B D JANKOVIC
Citations
Jun 10, 1998·Anesthesia and Analgesia·M YabeM Fujimori
Mar 26, 2003·European Journal of Anaesthesiology·P KrankeN Roewer
Mar 26, 2003·European Journal of Anaesthesiology·J Y Hong, I H Lee
Mar 26, 2003·European Journal of Anaesthesiology·J A BlunkW Koppert
Mar 26, 2003·European Journal of Anaesthesiology·M D CarcelesM L Laorden
Mar 26, 2003·European Journal of Anaesthesiology·H A LeatherP F Wouters
Mar 26, 2003·European Journal of Anaesthesiology·P BozkurtM Hacibekiroğlu
Mar 26, 2003·European Journal of Anaesthesiology·T P WeberM Booke
Mar 26, 2003·European Journal of Anaesthesiology·Y Leykin, F Rubulotta
Mar 26, 2003·European Journal of Anaesthesiology·S KobayashiS Sato
Mar 26, 2003·European Journal of Anaesthesiology·S G Sakka, A Meier-Hellmann
Mar 26, 2003·European Journal of Anaesthesiology·M SchywalskyH Schwilden
Mar 26, 2003·European Journal of Anaesthesiology·C NaughtonR O Feneck
Mar 26, 2003·European Journal of Anaesthesiology·G Haeseler, M Leuwer