PMID: 9552781Apr 29, 1998Paper

Bupivacaine-induced convulsion is suppressed by MK-801

Regional Anesthesia and Pain Medicine
T KasabaM Takasaki

Abstract

Not only the facilitation of inhibitory synapses but also the suppression of excitatory synapses may be effective in treating convulsion induced by local anesthetics. The effects of MK-801, a N-methyl-D-aspartate (NMDA) receptor antagonist, on bupivacaine-induced convulsion and hemodynamic changes were studied. Cortex and hippocampal (A4; L5.5; H8) electroencephalogram (EEG), heart rate, and mean arterial pressure were measured in 21 cats anesthetized with urethane. Blood samples were obtained when cats demonstrated arrhythmias, convulsed, and became hypotensive. In the control group (n = 7), bupivacaine was continuously infused until a hypotensive state of 40 mm/Hg was reached. In the MK-801 pretreated group (n = 7), MK-801 (0.5 mg/kg) was injected intravenously 15 minutes before the bupivacaine injection. In the MK-801 treatment group (n = 7), MK-801 (0.5 mg/kg) was injected intravenously at the appearance of convulsive EEG after the bupivacaine injection. Bupivacaine produced convulsion in the control group (17.1 +/- 2.4 microg/mL), but not in the MK-801 pretreated group. In the treatment group, convulsive EEG was suppressed gradually after injection of MK-801. The mean plasma bupivacaine concentrations (microg/mL) reaching ...Continue Reading

Citations

Aug 11, 2000·European Journal of Pharmacology·M SugimotoI Yoshiya
Jun 8, 2001·Journal of Pharmacological and Toxicological Methods·L A Ladd, L E Mather
Jun 21, 2013·Veterinary Anaesthesia and Analgesia·Yael Shilo-BenjaminiErik R Wisner
May 25, 2016·Veterinary Anaesthesia and Analgesia·Yael Shilo-BenjaminiPeter J Pascoe
May 27, 2016·American Journal of Veterinary Research·Javier BenitoPaulo V Steagall

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