PMID: 11915063Mar 27, 2002Paper

Buprenorphine added to the local anesthetic for axillary brachial plexus block prolongs postoperative analgesia

Regional Anesthesia and Pain Medicine
Kenneth D CandidoC D Franco

Abstract

Buprenorphine added to local anesthetic solutions for supraclavicular block was found to triple postoperative analgesia duration in a previous study when compared with local anesthetic block alone. That study, however, did not control for potentially confounding factors, such as the possibility that buprenorphine was affecting analgesia through intramuscular absorption or via a spinal mechanism. To specifically delineate the role of buprenorphine in peripherally mediated opioid analgesia, the present study controlled for these 2 factors. Sixty American Society of Anesthesiologists (ASA) P.S. I and II, consenting adults for upper extremity surgery, were prospectively assigned randomly in double-blind fashion to 1 of 3 groups. Group I received local anesthetic (1% mepivacaine, 0.2% tetracaine, epinephrine 1:200,000), 40 mL, plus buprenorphine, 0.3 mg, for axillary block, and intramuscular (IM) saline. Group II received local anesthetic-only axillary block, and IM buprenorphine 0.3 mg. Group III received local anesthetic-only axillary block and IM saline. Postoperative pain onset and intensity were compared, as was analgesic medication use. The mean duration of postoperative analgesia was 22.3 hours in Group I; 12.5 hours in group...Continue Reading

Citations

Jan 17, 2014·Journal of Maxillofacial and Oral Surgery·S Praveen KumarS M Kotrashetti
Jul 20, 2002·Regional Anesthesia and Pain Medicine·Joseph M NealQuinn H Hogan
Mar 14, 2009·Regional Anesthesia and Pain Medicine·Joseph M NealQuinn H Hogan
Nov 19, 2009·Regional Anesthesia and Pain Medicine·Brian A WilliamsSteven L Orebaugh
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Sep 5, 2017·World Journal of Clinical Cases·Amlan SwainDevi Prasad Samaddar

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