Buprenorphine as a stimulus in drug discrimination learning: an assessment of mu and kappa receptor activity

Pharmacology, Biochemistry, and Behavior
S. Pournaghash, A.L. Riley

Abstract

Using the conditioned taste aversion baseline of drug discrimination learning, different groups of animals were trained to discriminate either buprenorphine or morphine from distilled water. Specifically, animals were injected with buprenorphine or morphine prior to a saccharin-LiCl pairing and the drug vehicle prior to saccharin alone. By the fifth conditioning trial, animals differentially consumed saccharin on the basis of administration of the drug or its vehicle. In subsequent generalization tests, buprenorphine stimulus control generalized completely to the mu agonist morphine in four of the five subjects tested, while morphine stimulus control completely generalized to buprenorphine in two of five subjects and partially generalized in the remaining three. Buprenorphine failed to generalize to the relatively selective kappa antagonist MR2266 and the broad-based antagonist diprenorphine. Morphine also failed to generalize to MR2266, but did generalize to diprenorphine. That morphine and buprenorphine displayed some degree of cross-generalization suggests that these compounds share some stimulus property, presumably their agonist activity at the mu receptor, and that the mu activity of these compounds was used in the establ...Continue Reading

References

Aug 1, 1977·British Journal of Pharmacology·A CowanI R Macfarlane
Nov 1, 1992·Pharmacology, Biochemistry, and Behavior·S.T. Smurthwaite, A.L. Riley
Jan 1, 1992·Pharmacology, Biochemistry, and Behavior·G W StevensonA.L. Riley
Jan 1, 1992·Pharmacology, Biochemistry, and Behavior·S.T. SmurthwaiteA.L. Riley
Jun 1, 1991·Pharmacology, Biochemistry, and Behavior·A M YoungG Kapitsopoulos
Aug 1, 1991·Pharmacology, Biochemistry, and Behavior·F Woudenberg, T H Hijzen
Jan 1, 1990·Journal of Experimental Psychology. Animal Behavior Processes·G M MartinD van der Kooy
Mar 1, 1990·Journal of Medicinal Chemistry·D M Zimmerman, J D Leander
Jan 1, 1989·Psychopharmacology·D V Gauvin, A M Young
Jan 1, 1989·Pharmacology, Biochemistry, and Behavior·J P MastropaoloA.L. Riley
Oct 26, 1988·European Journal of Pharmacology·S S Negus, L A Dykstra
Jul 14, 1988·European Journal of Pharmacology·J D Leander
Jun 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·J MagnanH W Kosterlitz
Sep 15, 1980·Life Sciences·D RömerA M Akkerman
Jul 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·K J ChangP Cuatrecasas
Jan 1, 1982·Psychopharmacology·R B Carter, J D Leander
Jan 1, 1983·Progress in Neuro-psychopharmacology & Biological Psychiatry·P L Wood
Apr 1, 1983·British Journal of Pharmacology·R M BryantM B Tyers
Apr 1, 1983·British Journal of Pharmacology·J D Leander
Feb 1, 1993·Pharmacology, Biochemistry, and Behavior·P.M. MeltonA.L. Riley
Nov 1, 1991·Behavioural Pharmacology·I. Lucki, J.M. Marcoccia

Citations

Dec 1, 1994·Pharmacology, Biochemistry, and Behavior·B K ParkerM Miller
Jul 1, 1994·Pharmacology, Biochemistry, and Behavior·S.T. Smurthwaite, A.L. Riley
Jan 1, 1994·Peptides·G A OlsonA J Kastin
Jan 29, 2002·Pharmacology, Biochemistry, and Behavior·G W StevensonAntony L Riley
Jul 27, 1999·Pharmacology, Biochemistry, and Behavior·S D GrabusA.L. Riley
May 20, 2006·Journal of Sex & Marital Therapy·H KnegteringDurk Wiersma

Related Concepts

MR 2266, (2alpha,6alpha,11R*)-isomer
Metazoa
Benzomorphan
Buprenex
Revivon
Discrimination Learning
Generalization, Stimulus
Morphine Sulfate (2: 1), Pentahydrate
Narcotic Antagonists
Taste Perception

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Systemic Juvenile Idiopathic Arthritis

Systemic juvenile idiopathic arthritis is a rare rheumatic disease that affects children. Symptoms include joint pain, but also fevers and skin rashes. Here is the latest on this disease.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Pontocerebellar Hypoplasia

Pontocerebellar hypoplasias are a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable neocortical atrophy and severe mental and motor impairments. Here is the latest research on pontocerebellar hypoplasia.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Chronic Traumatic Encephalopathy

Chronic Traumatic Encephalopathy (CTE) is a progressive degenerative disease that occurs in individuals that suffer repetitive brain trauma. Discover the latest research on traumatic encephalopathy here.