Buprenorphine as a stimulus in drug discrimination learning: an assessment of mu and kappa receptor activity

Pharmacology, Biochemistry, and Behavior
S. Pournaghash, A.L. Riley


Using the conditioned taste aversion baseline of drug discrimination learning, different groups of animals were trained to discriminate either buprenorphine or morphine from distilled water. Specifically, animals were injected with buprenorphine or morphine prior to a saccharin-LiCl pairing and the drug vehicle prior to saccharin alone. By the fifth conditioning trial, animals differentially consumed saccharin on the basis of administration of the drug or its vehicle. In subsequent generalization tests, buprenorphine stimulus control generalized completely to the mu agonist morphine in four of the five subjects tested, while morphine stimulus control completely generalized to buprenorphine in two of five subjects and partially generalized in the remaining three. Buprenorphine failed to generalize to the relatively selective kappa antagonist MR2266 and the broad-based antagonist diprenorphine. Morphine also failed to generalize to MR2266, but did generalize to diprenorphine. That morphine and buprenorphine displayed some degree of cross-generalization suggests that these compounds share some stimulus property, presumably their agonist activity at the mu receptor, and that the mu activity of these compounds was used in the establ...Continue Reading


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Related Concepts

MR 2266, (2alpha,6alpha,11R*)-isomer
Discrimination Learning
Generalization, Stimulus
Morphine Sulfate (2: 1), Pentahydrate
Narcotic Antagonists
Taste Perception

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