Buprenorphine for the management of opioid withdrawal

The Cochrane Database of Systematic Reviews
L GowingJ White

Abstract

Managed withdrawal is a necessary step prior to drug-free treatment. It may also represent the end point of maintenance treatment. To assess the effectiveness of interventions involving the use of buprenorphine to manage opioid withdrawal, for withdrawal signs and symptoms, completion of withdrawal and adverse effects. We searched the Cochrane Central Register of Controlled Trials (The Cochrane Library, including the Cochrane Drugs and Alcohol Group trials register, Issue 3, 2005), MEDLINE (January 1966 to August 2005), EMBASE (January 1985 to August 2005), PsycINFO (1967 to August 2005), CINAHL(1982 to July 2005) and reference lists of articles. Experimental interventions involved the use of buprenorphine to modify the signs and symptoms of withdrawal in participants who were primarily opioid dependent. Comparison interventions involved reducing doses of methadone, alpha2 adrenergic agonists, symptomatic medications or placebo, or different buprenorphine-based regimes. One reviewer assessed studies for inclusion and methodological quality, and undertook data extraction. Inclusion decisions and the overall process was confirmed by consultation between all three reviewers. Eighteen studies (14 randomised controlled trials), invo...Continue Reading

Citations

Oct 25, 2007·Health Affairs·Colleen L Barry, Jody L Sindelar
Dec 14, 2007·The International Journal on Drug Policy·Adrian Carter, Wayne Hall
Mar 13, 2015·Iranian Red Crescent Medical Journal·Hassan ZiaaddiniMahin Eslami
Nov 26, 2009·Drug and Alcohol Review·Adam R WinstockToby Lea
Jan 20, 2009·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Shahram Shaygani, Helge Waal
Sep 7, 2007·CNS Spectrums·Dan J SteinJaak Panksepp
Oct 26, 2018·The American Journal of Emergency Medicine·David H CisewskiBrit Long
Aug 18, 2021·The American Journal of Drug and Alcohol Abuse·Lien-Chung Wei, Hung-Yu Chan

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