Buprenorphine in the treatment of opiate dependence

Journal of Psychoactive Drugs
Donald R Wesson, David E Smith

Abstract

Compelling clinical evidence establishes that buprenorphine is similar to methadone in efficacy for opiate detoxification and maintenance but safer than methadone in an overdose situation. The Drug Abuse Treatment Act of 2000 (DATA 2000) enabled US physicians with additional training to prescribe buprenorphine to a limited number of opiate-dependent patients. The sublingual tablets Subutex (buprenorphine alone) and Suboxone (a combination of buprenorphine and naloxone) meet the specifications of DATA 2000. Suboxone is intended to discourage intravenously administration and has less abuse potential than buprenorphine alone. Suboxone is generally recommended for maintenance treatment except for women who are pregnant. Subutex is recommended in treatment of pregnant women. A buprenorphine opiate withdrawal syndrome can occur in newborns. Although intravenous buprenorphine abuse is a significant public health problem in some countries, buprenorphine alone or in combination with naloxone has less potential for abuse than heroin and some prescription opiates, such as oxycodone. Pharmacotherapy from physicians' offices makes buprenorphine treatment acceptable to some opiate-dependent patients who would not accept treatment in traditio...Continue Reading

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Citations

Nov 25, 2011·Journal of Psychoactive Drugs·David E Smith
Jul 15, 2015·The American Journal of Drug and Alcohol Abuse·Amber M Holbrook
Oct 2, 2012·Journal of Substance Abuse Treatment·Maureen HillhouseWalter Ling
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Sep 24, 2013·Forensic Science International : Synergy·Margareeta HäkkinenIlkka Ojanperä
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Nov 12, 2013·Journal of Substance Abuse Treatment·Sean M MurphyJohn R Roll
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May 15, 2021·Drug and Alcohol Dependence·Matthew F McLaughlinAvik Chatterjee
Jun 3, 2021·Biomolecules·Rosmara InfantinoLivio Luongo

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