Bupropion metabolism by human placenta.

Biochemical Pharmacology
Xiaoming WangTatiana N Nanovskaya

Abstract

Smoking during pregnancy is the largest modifiable risk factor for pregnancy-related morbidity and mortality. The success of bupropion for smoking cessation warrants its investigation for the treatment of pregnant patients. Nevertheless, the use of bupropion for the treatment of pregnant smokers requires additional data on its bio-disposition during pregnancy. Therefore, the aim of this investigation was to determine the metabolism of bupropion in placentas obtained from nonsmoking and smoking women, identify metabolites formed and the enzymes catalyzing their formation, as well as the kinetics of the reaction. Data obtained revealed that human placentas metabolized bupropion to hydroxybupropion, erythro- and threohydrobupropion. The rates for formation of erythro- and threohydrobupropion exceeded that for hydroxybupropion by several folds, were dependent on the concentration of bupropion and exhibited saturation kinetics with an apparent K(m) value of 40microM. Human placental 11beta-hydroxysteroid dehydrogenases were identified as the major carbonyl-reducing enzymes responsible for the reduction of bupropion to threo- and erythrohydrobupropion in microsomal fractions. On the other hand, CYP2B6 was responsible for the formatio...Continue Reading

References

May 1, 1990·American Journal of Public Health·L A FingerhutJ S Kendrick
Jun 1, 1989·Annals of Internal Medicine·D F WilliamsonJ S Kendrick
Mar 1, 1971·Toxicology and Applied Pharmacology·M R Juchau
Jan 1, 1980·Drug Metabolism Reviews·R L Felsted, N R Bachur
Nov 1, 1994·Molecular and Cellular Endocrinology·A L AlbistonZ S Krozowski
Jan 1, 1994·Critical Reviews in Toxicology·M Pasanen, O Pelkonen
Jul 31, 1999·Clinical Pharmacokinetics·S Zevin, N L Benowitz
Jun 6, 2000·Advanced Drug Delivery Reviews·M Pasanen
Nov 21, 2000·Obstetrics and Gynecology·K WisborgN J Secher
Jul 17, 2001·Seminars in Perinatology·M C Frederiksen
May 30, 2003·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Masuhiro NishimuraTetsuo Satoh
Jun 17, 2003·The Journal of Pharmacology and Experimental Therapeutics·Sujal V DeshmukhMahmoud S Ahmed
Jun 20, 2003·Neuropharmacology·Sharon MiksysRachel F Tyndale
Aug 12, 2003·European Journal of Pharmacology·Mikhail L BondarevRichard A Glennon
May 25, 2004·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Miia TurpeinenOlavi Pelkonen
Jul 9, 2004·Drug Metabolism Reviews·M Jane Cox Rosemond, John S Walsh
Jul 10, 2004·Biochemical Pharmacology·Tatiana N NanovskayaMahmoud S Ahmed
May 30, 2006·European Journal of Pharmacology·Hideaki ShimadaYorishige Imamura
Apr 28, 2007·Biochemical Pharmacology·Olga L ZharikovaMahmoud S Ahmed
Aug 5, 2008·American Journal of Obstetrics and Gynecology·Sarah J HemauerTatiana N Nanovskaya
May 12, 2009·The Journal of Steroid Biochemistry and Molecular Biology·Dirk Classen-HoubenBernhard Kueenburg
Aug 7, 2009·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Angela D EarhartTatiana Nanovskaya

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Citations

Jun 28, 2013·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Arne MeyerAlex Odermatt
Sep 30, 2015·Drug Metabolism Reviews·Iva BoušováPetra Matoušková
Nov 1, 2013·Drug Metabolism Reviews·Petra Malátková, Vladimír Wsól
Feb 22, 2012·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Jillissa C Molnari, Alan L Myers
Oct 4, 2013·Drug Metabolism and Pharmacokinetics·Lucie SkarydovaVladimir Wsol
May 17, 2011·Biochemical Pharmacology·Xiaoming WangTatiana N Nanovskaya
May 18, 2016·American Journal of Obstetrics and Gynecology·Valentina M FokinaTatiana N Nanovskaya
Oct 21, 2016·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Valentina M FokinaTatiana N Nanovskaya
Sep 7, 2017·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Ranjeet Prasad DashNuggehally R Srinivas
Nov 30, 2018·Drug Metabolism Letters·Lyrialle W HanQingcheng Mao
Aug 7, 2014·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Erik RyttingTatiana N Nanovskaya
Jul 29, 2015·Journal of Labelled Compounds & Radiopharmaceuticals·Jian LiLiqin Chen
Mar 5, 2020·Expert Review of Clinical Pharmacology·Ricardo Blanco-CastañedaMartha Sosa-Macías
Apr 6, 2021·Therapeutic Drug Monitoring·Emily E FayNina Isoherranen

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