Burden of cardiovascular disease in Japanese cancer patients and survivors: a single cancer-center study in Niigata City

International Journal of Clinical Oncology
Yuji OkuraTohru Minamino

Abstract

Cardiovascular disease (CVD) and cancer are major causes of death in Japan. As most CVDs are chronic and often aggravate, long-term follow-up is necessary. Although some cancer patients and survivors have CVD, its prognostic significance and prevalence are unknown. Therefore, we conducted a retrospective study at our center to determine the prevalence of cancer patients with CVD. In 2015, our 10-year (2005-2014) cancer registry was summarized. Comorbidities including left ventricular dysfunction, atrial fibrillation (AF), ischemic heart disease, aortic stenosis, venous thromboembolism (VTE), and elevation of N-terminal prohormone of brain natriuretic peptide (NT-proBNP) were examined. In total, 26,235 de novo cancer patients were registered and 16,130 survived until January 1, 2015. The 5-year survival rate was 64.0% for all cancer patients and 44.2% for cancer patients with CVD. Cox proportional hazards analysis adjusting for age, cancer stage, and body mass index revealed that AF [hazard ratio (HR) 1.219, male; P = 0.038], VTE (HR 1.517, male; P = 0.003 and HR 2.089, female; P < 0.001), and NT-proBNP elevation (HR 1.861, female; P = 0.002) were significantly associated with death. The CVD prevalence among cancer survivors in ...Continue Reading

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Citations

Jul 18, 2020·Japanese Journal of Clinical Oncology·Kazuko TajiriMasaki Ieda
Mar 25, 2019·International Journal of Clinical Oncology·Yuji OkuraTohru Minamino
Sep 20, 2019·Circulation Journal : Official Journal of the Japanese Circulation Society·Yuji OkuraTohru Minamino

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