Burden of disease associated with a COPD eosinophilic phenotype

International Journal of Chronic Obstructive Pulmonary Disease
Hector G OrtegaBeth Hahn

Abstract

Based on blood and sputum samples, up to 40% of patients with COPD have eosinophilic inflammation; however, there is little epidemiology data characterizing the health care burden within this sub-population. Given that COPD-attributable medical costs in the USA are predicted to approach $50 billion by 2020, we analyzed the effect of blood eosinophil counts and exacerbations on health care resource utilization and costs. This cross-sectional study used electronic medical records and insurance claims data from the Reliant Medical Group (January 2011-December 2015). Eligible patients were ≥40 years of age, continuously enrolled during the year of interest (2012, 2013, 2014, or 2015), had ≥1 COPD-related code in the preceding year, and documented maintenance therapy use. Patients with ≥1 blood eosinophil count recorded were stratified into 2 cohorts: <150 cells/µL and ≥150 cells/µL. Endpoints included demographics, clinical characteristics, health care resource utilization, and costs. The impact of blood eosinophil count and exacerbation patterns on health care resource utilization and costs was assessed with multivariate analyses. On average, 2,832 eligible patients were enrolled annually, of whom ~28% had ≥1 eosinophil count reco...Continue Reading

Citations

Apr 16, 2019·Expert Opinion on Pharmacotherapy·Chitra Lal, Charlie Strange
Feb 18, 2020·Archivos de bronconeumología·Marc MiravitllesBernardino Alcázar
May 22, 2020·The World Allergy Organization Journal·Namhee KwonAlvaro A Cruz
May 18, 2021·Respiratory Investigation·Sumitra ShantakumarBarry Gribben
Jul 30, 2021·International Journal of Chronic Obstructive Pulmonary Disease·Natasha A WinterMichael Fricker
Sep 4, 2019·Respiration; International Review of Thoracic Diseases·Stephan F van Eeden, James C Hogg
Jun 27, 2021·The European Respiratory Journal·Victoria S BensonNamhee Kwon

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