Burden of herpes simplex virus encephalitis in the United States

Journal of Neurology
S ModiP Mitsias

Abstract

Herpes simplex virus encephalitis (HSVE) is a disease of public health concern, but its burden on the healthcare of United States has not been adequately assessed recently. We aimed to define the incidence, complications and outcomes of HSVE in the recent decade by analyzing data from a nationally representative database. Healthcare Cost and Utilization Project databases were utilized to identify patients with primary discharge diagnosis of HSVE. Annual hospitalization rate was estimated and several preselected inpatient complications were identified. Regression analyses were used to identify mortality predictors. Key epidemiological factors were compared with those from other countries. Total 4871 patients of HSVE were included in our study. The annual hospitalization rate was 10.3 ± 2.2 cases/million in neonates, 2.4 ± 0.3 cases/million in children and 6.4 ± 0.4 cases/million in adults. Median age was 57 years and male:female incidence ratio was 1:1. Rates of some central nervous system complications were seizures (38.4%), status epilepticus (5.5%), acute respiratory failure (20.1%), ischemic stroke (5.6%) and intracranial hemorrhage (2.7%), all of which were significantly associated with mortality. In-hospital mortality in n...Continue Reading

References

Oct 1, 1990·Journal of Medical Virology·E Puchhammer-StöcklC Kunz
Sep 1, 1988·Neuropathology and Applied Neurobiology·P G KennedyG B Clements
Nov 5, 1997·Journal of Neurology, Neurosurgery, and Psychiatry·N McGrathK F Powell
Jul 13, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Franck RaschilasFlore Rozenberg
Nov 17, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C A GlaserJ H Tureen
Sep 7, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Anders HjalmarssonBirgit Sköldenberg
Apr 2, 2009·Annals of Neurology·Meizan LaiJosep Dalmau
Sep 15, 2009·Pediatric Neurology·Antonetta M G SasMarie Claire Y de Wit
Nov 26, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Alexandra MaillesUNKNOWN Steering Committee and Investigators Group
Oct 19, 2010·The Lancet Infectious Diseases·Julia GranerodUNKNOWN UK Health Protection Agency (HPA) Aetiology of Encephalitis Study Group
Jul 8, 2011·Epidemiology and Infection·P BarbadoroE Prospero
Jun 20, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Javier RianchoJose Berciano
Jul 28, 2013·Clinical Neurology and Neurosurgery·Aida Rodríguez-SainzJuan Carlos Garcia-Monco
Apr 29, 2014·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Uluhan SiliUNKNOWN HSV Encephalitis Study Group
May 27, 2014·Japanese Journal of Infectious Diseases·Parul JainG Arun Kumar
Dec 30, 2014·Neurology·Tarun D SinghAlejandro A Rabinstein
Sep 22, 2015·Critical Care : the Official Journal of the Critical Care Forum·Youenn JouanAntoine Guillon
Nov 7, 2015·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Panagiotis ZisAntonios Tavernarakis

❮ Previous
Next ❯

Citations

Feb 27, 2018·BMJ Case Reports·Amos LalAftab Ahmad
Mar 29, 2019·Current Opinion in Infectious Diseases·Jean Paul Stahl, Alexandra Mailles
Jul 12, 2019·Intensive Care Medicine·P JaquetUNKNOWN ENCEPHALITICA study group
Jul 16, 2019·Current Opinion in Critical Care·Christopher P Robinson, Katharina M Busl
Feb 20, 2020·MMW Fortschritte der Medizin·Susanne Dyckhoff-ShenMatthias Klein
Jan 25, 2021·QJM : Monthly Journal of the Association of Physicians·K Oguni, M Yaegashi
May 11, 2020·Trends in Microbiology·Maria Elena MarcocciGiovanna De Chiara
Jun 27, 2021·European Archives of Psychiatry and Clinical Neuroscience·Rodolfo Furlan DamianoOrestes Forlenza
Aug 2, 2021·Journal of Neuroimmunology·Qi-Lun LaiYin-Xi Zhang
Jan 25, 2019·Neurology·Jesse CohenArun Venkatesan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.