Burden of HIV-associated histoplasmosis compared with tuberculosis in Latin America: a modelling study

The Lancet Infectious Diseases
Antoine A AdenisMathieu Nacher

Abstract

Fungal infections remain a major contributor to the opportunistic infections that affect people living with HIV. Among them, histoplasmosis is considered neglected, often being misdiagnosed as tuberculosis, and is responsible for numerous deaths in Latin America. The objective of this study was to estimate the burden of HIV-associated histoplasmosis compared with tuberculosis in Latin American countries. For this modelling study, we estimated prevalence of previous exposure to Histoplasma capsulatum, HIV-associated histoplasmosis annual incidence, and number of deaths in 2012 in Latin American countries based on historical histoplasmin skin test studies in the general population, with an antigen dilution level of more than 1/10. Studies were identified in a literature search. Data on HIV-associated tuberculosis were extracted from the WHO notifications and outcomes tables and data on people living with HIV were extracted from the UNAIDS report for the year 2012. We systematically propagated uncertainty throughout all the steps of the estimation process. Among 1310 articles identified as of June 1, 2015, 24 articles were included in the study, representing 129 histoplasmin skin test studies led in the general population of Latin...Continue Reading

Citations

Aug 1, 2019·Emerging Microbes & Infections·Jacob BakerDavid W Denning
Aug 27, 2019·PLoS Neglected Tropical Diseases·Matheus da Silva ZattiRaquel Cordeiro Theodoro
Jul 6, 2020·Expert Review of Anti-infective Therapy·Andrés Tirado-SánchezAlexandro Bonifaz
Apr 14, 2019·Current Infectious Disease Reports·Daniel L BourquePaul E Sax
Feb 27, 2020·Open Forum Infectious Diseases·Adriana M RauseoAndrej Spec
Jul 25, 2020·PloS One·Mathieu NacherPierre Couppié
Aug 9, 2020·International Journal of Environmental Research and Public Health·Albertus J SmitNeville A Sweijd
Aug 14, 2019·Journal of Fungi·Diego H Caceres, Audrey Valdes
Jun 16, 2019·Virchows Archiv : an International Journal of Pathology·Antonio E M PalharesMarcus Lacerda
Dec 22, 2019·Journal of Fungi·Mathieu Nacher
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May 16, 2020·Open Forum Infectious Diseases·Jacob BakerDavid W Denning
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Oct 20, 2020·Frontiers in Cellular and Infection Microbiology·Duc NguyenAntoine Adenis
Jan 23, 2021·PLoS Neglected Tropical Diseases·Mathieu NacherPierre Couppié
Jan 30, 2021·Critical Reviews in Microbiology·Alison Felipe Alencar ChavesWagner Luiz Batista
Nov 19, 2019·Current Opinion in Microbiology·Anita Sil
Feb 9, 2021·European Journal of Pediatrics·Miguel García-BoyanoGreta Miño-León
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Mar 7, 2021·Journal of Fungi·Shawn R LockhartAnastasia P Litvintseva
Apr 2, 2021·Frontiers in Cellular and Infection Microbiology·Mathieu NacherPierre Couppié
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Jul 1, 2019·Microbes and Infection·Guilhem JanbonChristophe d'Enfert
May 1, 2021·Journal of Fungi·Leticia Bernal-MartínezMaría José Buitrago

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