Burden of illness in patients with treatment refractory myasthenia gravis

Muscle & Nerve
Nicole M Engel-NitzNicholas J Silvestri

Abstract

This study assessed the clinical burden of refractory myasthenia gravis (MG), relative to nonrefractory MG. Rates of myasthenic crises, exacerbations, inpatient hospitalizations, and emergency room (ER) visits over a 1-year period were measured for 403 refractory, 3,811 nonrefractory, and 403 non-MG control patients from two administrative health plan databases. Compared with nonrefractory patients, a significantly greater percentage of refractory patients had at least one myasthenic crisis (21.3% vs. 6.1%; P < 0.001) and at least one exacerbation (71.2% vs. 32.4%; P < 0.001) over a 1-year period. Refractory patients were also significantly more likely to be hospitalized and/or have an ER visit than nonrefractory patients and non-MG controls (P < 0.001 for all). Refractory MG patients have significantly greater clinical burden and are more likely to utilize intensive healthcare resources than nonrefractory patients. Furthermore, refractory patients may be at greater risk of crises throughout the disease course than previous studies have suggested. Muscle Nerve, 2018.

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Citations

Feb 16, 2019·Muscle & Nerve·Srikanth MuppidiUNKNOWN Regain Study Group
Mar 8, 2019·Journal of Medical Economics·Linda HarrisSaiju Jacob
Dec 13, 2019·Journal of Neurology·Jakob RathFritz Zimprich
May 29, 2019·Journal of Clinical Neuromuscular Disease·Audra N BoscoeGary R Cutter
Jul 24, 2020·Annals of Clinical and Translational Neurology·Renato MantegazzaUNKNOWN REGAIN study group
Jul 14, 2020·Therapeutic Advances in Neurological Disorders·Valentina Vélez-SantamaríaCarlos Casasnovas
Jun 26, 2020·Frontiers in Immunology·Khaled AlbazliJames F Howard
Mar 12, 2019·Therapeutic Advances in Neurological Disorders·Christiane Schneider-GoldTobias Ruck
Sep 24, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M AlcantaraV Bril
Jan 12, 2021·Frontiers in Neurology·Jan Lykke Scheel Thomsen, Henning Andersen
Feb 19, 2021·Journal of Central Nervous System Disease·Michael SchroeterAndreas Meisel
Apr 9, 2021·Journal of Neurology·Adi Wilf-YarkoniMark A Hellmann
May 27, 2021·Muscle & Nerve·Jan L S ThomsenHenning Andersen
Aug 13, 2021·Muscle & Nerve·Karissa L Gable, Lisa D Hobson-Webb

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