Burden of infection and insulin resistance in healthy middle-aged men

Diabetes Care
José-Manuel Fernández-RealWifredo Ricart

Abstract

We hypothesized that burden of infection could be associated with chronic low-grade inflammation, resulting in insulin resistance. We aimed to study the effect of exposure to four infections on insulin sensitivity in apparently healthy middle-aged men (n = 124). By inclusion criteria, all subjects were hepatitis C virus antibody seronegative. Each study subject's serum was tested for specific IgG class antibodies against herpes simplex virus (HSV)-1, HSV-2, enteroviruses, and Chlamydia pneumoniae through the use of quantitative in vitro enzyme-linked immunosorbent assays. Insulin sensitivity was evaluated using minimal model analysis. The HSV-2 titer was negatively associated with insulin sensitivity even after controlling for BMI, age, and C-reactive protein (CRP). The associations were stronger when considering the infection burden. In particular, in those subjects who were seropositive for C. pneumoniae, the relationship between the quantitative seropositivity index (a measure of the exposure to various pathogens) and insulin sensitivity was strengthened (r = -0.50, P < 0.0001). We also observed decreasing mean insulin sensitivity index with increasing seropositivity score in subjects positive for enteroviruses. In the latte...Continue Reading

Citations

Mar 6, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J M Fernández-RealW Ricart
Dec 5, 2009·Critical Reviews in Food Science and Nutrition·Emily J McAllisterDavid B Allison
Jul 28, 2010·American Journal of Epidemiology·Eric T RobertsAllison E Aiello
Feb 7, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Anna ZajacovaAllison E Aiello
Aug 30, 2008·Infection and Immunity·Chengming WangBernhard Kaltenboeck
Jan 27, 2012·Diabetes Care·Christie Y JeonAllison E Aiello
May 4, 2011·World Journal of Diabetes·Cheng-Ming Wang, Bernhard Kaltenboeck
May 2, 2014·World Journal of Gastroenterology : WJG·Cong HeNong-Hua Lu
Aug 3, 2010·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·W Ricart, J M Fernández-Real
Apr 14, 2009·Diabetes Research and Clinical Practice·Abdolali EbrahimiZahra Sanjdideh
Jan 21, 2009·Social Science & Medicine·Jennifer Beam DowdAllison Aiello
Jun 3, 2009·Journal of Public Health Dentistry·Hideaki HayashidaToshiyuki Saito
Nov 1, 2012·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·J C K Wells
May 26, 2010·European Journal of Clinical Investigation·José Manuel Fernández-RealWifredo Ricart
Jan 13, 2011·Gerodontology·Ola NorderydHenrik Jansson
Dec 17, 2010·Clinical Endocrinology·Renato PasqualiRichard S Legro
Dec 2, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J M Moreno-NavarreteJ M Fernández-Real

❮ Previous
Next ❯

Related Concepts

Related Feeds

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.