Burden of Liver Disease among Community-Based People Who Inject Drugs (PWID) in Chennai, India

PloS One
Sunil S SolomonShruti H Mehta

Abstract

We characterize the burden of liver disease in a cohort of PWID in Chennai, India, with a high prevalence of HCV. 1,042 PWID were sampled through community outreach in Chennai. Participants underwent fasting blood draw, questionnaire and an examination that included liver stiffness assessment using transient elastography (Fibroscan) and assessment of steatosis via ultrasound. The median age was 39 years, all were male, 14.8% were HIV infected and 35.6% were HCV antibody positive, of whom 78.9% were chronically infected (HCV RNA positive). Median liver stiffness was 6.2 kPA; 72.9% had no evidence of or mild stiffness, 14.5% had moderate stiffness, and 12.6% had evidence of severe stiffness/cirrhosis. Prevalence of severe stiffness/cirrhosis was significantly higher among persons who were older, had a longer duration of injecting drugs, higher body mass index, higher prevalence of insulin resistance, higher prevalence of steatosis, higher HCV RNA levels and evidence of alcohol dependence. An estimated 42.1% of severe stiffness/cirrhosis in this sample was attributable to HCV. 529 (53.0%) had some evidence of steatosis. Prevalence of steatosis was higher among those who had larger waist circumference, insulin resistance, higher HD...Continue Reading

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Citations

Feb 6, 2017·European Journal of Gastroenterology & Hepatology·Mário J SilvaElizabeth Pádua
Jun 24, 2017·Drug Testing and Analysis·Pei-Pei PanZhou Du
Jun 10, 2019·Indian Journal of Pediatrics·Devika GuptaDipendra K Mitra
Sep 25, 2017·Journal of Clinical and Translational Hepatology·Gautam Ray
Oct 27, 2020·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Akihiro TamoriNorifumi Kawada
Aug 18, 2021·Movement Disorders Clinical Practice·Eoin MulroyKailash P Bhatia

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Methods Mentioned

BETA
biopsy
blood draw
ELISA
biopsies

Software Mentioned

Fibroscan

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