Burden of Serious Infections in Adults With Systemic Lupus Erythematosus: A National Population-Based Study, 1996-2011

Arthritis Care & Research
Maria G TektonidouMichael M Ward

Abstract

To compare rates of hospitalization for serious infections, trends in rates from 1996 to 2011, and in-hospital mortality between patients with systemic lupus erythematosus (SLE) and those without SLE in a national sample. We analyzed hospitalizations for pneumonia, bacteremia/sepsis, urinary tract infections, skin infections, and opportunistic infections among adults in the Nationwide Inpatient Sample. We compared rates of hospitalization yearly among patients with SLE and the general population. We also computed odds ratios (ORs) for in-hospital mortality. In 1996, the estimated number of hospitalizations for pneumonia in patients with SLE was 4,382, followed by sepsis (2,305), skin infections (1,422), urinary tract infections (643), and opportunistic infections (370). Rates were much higher in patients with SLE than in those without SLE, with age-adjusted relative risks ranging from 5.7 (95% confidence interval [95% CI] 5.5-6.0) for pneumonia to 9.8 (95% CI 9.1-10.7) for urinary tract infection in 1996. Risks increased over time, so that by 2011, all relative risks exceeded 12.0. Overall risk of in-hospital mortality was higher in SLE only for opportunistic infections (adjusted OR 1.52 [95% CI 1.12-2.07]). However, in pneumon...Continue Reading

References

Feb 7, 1998·Medical Care·A ElixhauserR M Coffey
Apr 18, 2003·The New England Journal of Medicine·Greg S MartinMarc Moss
Dec 24, 2005·Autoimmunity·Gisele Zandman-Goddard, Yehuda Shoenfeld
Jul 27, 2006·Arthritis and Rheumatism·S BernatskyR Ramsey-Goldman
Mar 10, 2007·Journal of Clinical Epidemiology·Sebastian SchneeweissDaniel H Solomon
Feb 2, 2008·Arthritis and Rheumatism·Michael M Ward
Sep 17, 2008·The Journal of Rheumatology·Murray B UrowitzVernon T Farewell
Jan 28, 2009·Scandinavian Journal of Infectious Diseases·Su Jin JeongJune Myung Kim
Jul 17, 2009·Arthritis Research & Therapy·Guillermo Ruiz-IrastorzaCiriaco Aguirre
Aug 28, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Krista L Yorita ChristensenLawrence B Schonberger
Mar 17, 2011·Circulation. Heart Failure·Jon A Kobashigawa
May 3, 2011·Current Opinion in Rheumatology·Claire BarberPaul R Fortin
Apr 5, 2012·JAMA : the Journal of the American Medical Association·Peter K LindenauerMichael B Rothberg
Jul 6, 2013·Annals of the Rheumatic Diseases·Frédéric A Houssiau, David Isenberg
Nov 10, 2013·Critical Care Medicine·Elizabeth K StevensonAllan J Walkey
Mar 13, 2014·Journal of Crohn's & Colitis·J F RahierUNKNOWN European Crohn's and Colitis Organisation (ECCO)
Jun 6, 2014·Respiratory Medicine·Mette SøgaardReimar W Thomsen

❮ Previous
Next ❯

Citations

Nov 28, 2015·Rheumatic Diseases Clinics of North America·Jameel YoussefKevin L Winthrop
Oct 26, 2016·Journal of Autoimmunity·Hélène Jeltsch-David, Sylviane Muller
Dec 3, 2017·Applied and Environmental Microbiology·Xin M LuoAdegbenga A Bankole
Nov 20, 2018·Lupus·C González-EchavarriUNKNOWN RELES, Autoimmune Diseases Study Group GEAS
Jun 18, 2017·The Journal of Rheumatology·Kaien GuMurray B Urowitz
Jun 2, 2020·Expert Review of Clinical Immunology·Megan R W Barber, Ann E Clarke
Jul 30, 2020·Lupus·Ana Suárez-AvellanedaGabriel J Tobón
Sep 1, 2020·AACN Advanced Critical Care·Erin K Gasser, Hildy M Schell-Chaple
May 6, 2020·The European Respiratory Journal·Marios RossidesElizabeth V Arkema
Jul 13, 2020·Rheumatology International·Efstathios KastritisPetros P Sfikakis
Sep 26, 2020·Pediatric Rheumatology Online Journal·Taha Al-ShaikhlyEric J Allenspach
Apr 23, 2015·Nature Reviews. Rheumatology·Jessica Widdifield, Sasha Bernatsky
Mar 18, 2020·Case Reports in Infectious Diseases·Rochelle HardieYamen Homsi
Jul 13, 2017·Microbiome·Qinghui MuXin M Luo
Jul 1, 2020·Arthritis Research & Therapy·Jasvinder A Singh, John D Cleveland
Nov 10, 2020·ACR Open Rheumatology·Augustine M ManadanJoel A Block
Sep 13, 2020·Clinical Medicine : Journal of the Royal College of Physicians of London·Elizabeth ReillyRaj Sengupta

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
Richard D Wilson
Journal of the American Society of Nephrology : JASN
Sushrut S WaikarGlenn M Chertow
© 2022 Meta ULC. All rights reserved