Burden of tuberculosis at post mortem in inpatients at a tertiary referral centre in sub-Saharan Africa: a prospective descriptive autopsy study

The Lancet Infectious Diseases
Matthew BatesA Zumla

Abstract

Patients with subclinical tuberculosis, smear-negative tuberculosis, extrapulmonary tuberculosis, multidrug-resistant tuberculosis, and asymptomatic tuberculosis are difficult to diagnose and may be missed at all points of health care. We did an autopsy study to ascertain the burden of tuberculosis at post mortem in medical inpatients at a tertiary care hospital in Lusaka, Zambia. Between April 5, 2012, and May 22, 2013, we did whole-body autopsies on inpatients aged at least 16 years who died in the adult inpatient wards at University Teaching Hospital, Lusaka, Zambia. We did gross pathological and histopathological analysis and processed lung tissues from patients with tuberculosis through the GeneXpert MTB/RIF assay to identify patients with multidrug-resistant tuberculosis. The primary outcome measure was specific disease or diseases stratified by HIV status. Secondary outcomes were missed tuberculosis, multidrug-resistant tuberculosis, and comorbidities with tuberculosis. Data were analysed using Pearson χ(2), the Mann-Whitney U test, and binary logistic regression. The median age of the 125 included patients was 35 years (IQR 29-43), 80 (64%) were men, and 101 (81%) were HIV positive. 78 (62%) patients had tuberculosis, o...Continue Reading

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Citations

Jan 7, 2016·Expert Review of Molecular Diagnostics·Matthew Bates, Alimuddin Zumla
Feb 9, 2016·Diagnostics·Ruth McNerney
Oct 16, 2015·The Lancet Infectious Diseases·Yogesh Jain, Pramod Upadhyay
Oct 16, 2015·The Lancet Infectious Diseases·Syed Ather HussainRitesh G Menezes
Jul 30, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Alimuddin ZumlaUNKNOWN Host-Directed Therapies Network (HDT-NET) Consortium
Sep 27, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Marco SchitoAlimuddin Zumla
Mar 15, 2015·The Lancet Infectious Diseases·Rasika Rampatige, Charles F Gilks
Jul 2, 2016·BMC Medicine·Matthew BatesAlimuddin Zumla
Oct 30, 2016·Transactions of the Royal Society of Tropical Medicine and Hygiene·Noriah MarabaViolet Chihota
Jan 31, 2017·Immunological Reviews·Bette KorberBeatrice H Hahn
Nov 12, 2016·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Tom HellerMartin P Grobusch
Mar 31, 2017·BMC Infectious Diseases·Pascalina Chanda-KapataFrank Cobelens
Mar 21, 2017·International Journal of Mycobacteriology·Pascal PolepoleMatthew Bates
Dec 27, 2017·The Pediatric Infectious Disease Journal·Sabine BélardHeather J Zar
Jul 28, 2019·The European Respiratory Journal·Alberto L Garcia-BasteiroMiguel J Martínez
Oct 3, 2019·The European Respiratory Journal·Byron William Patrick ReeveGrant Theron
Dec 14, 2019·The European Respiratory Journal·Jamshed BomanjiUNKNOWN International Atomic Energy Agency Extra-pulmonary TB Consortium
Jan 7, 2017·Current Opinion in HIV and AIDS·Lesley ScottChristopher M Gilpin
Sep 18, 2020·Journal of Clinical Medicine·Aysha ArshadVishwanath Venketaraman
Sep 27, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Marco SchitoAlimuddin Zumla
Feb 11, 2016·Scientific Reports·Alberto L García-BasteiroMiguel J Martínez
Jul 20, 2018·Clinical Microbiology Reviews·Paul K DrainDavid R Sherman
Oct 9, 2019·The Journal of Infectious Diseases·Ruvandhi R NathavitharanaSamuel G Schumacher
Dec 10, 2020·Epidemiologia E Serviços De Saúde : Revista Do Sistema Unico De Saúde Do Brasil·Ursila Manga AridjaElisabeth Carmen Duarte
Mar 25, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Frauke RudolfChristian Wejse
Aug 25, 2021·Journal of Health, Population, and Nutrition·Pascal PolepoleLuwen Zhang

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