Burkholderia cepacia complex infections: More complex than the bacterium name suggest

The Journal of Infection
Maroun M Sfeir

Abstract

Burkholderia cepacia complex (Bcc) is an emerging pathogen causes life-threatening infections in cystic fibrosis patients. This narrative review aims to highlight an update on the epidemiology, the microbiological diagnostic methods, the antimicrobial resistance mechanisms, and the most current as well the promising therapeutic options for Bcc. Although Bcc plays a role in crop growth due to its fungicidal activity and pesticide metabolizer, it has been frequently implicated in outbreaks in the United States and Worldwide due to contaminated medicines or medical devices. Phenotypic methods of microbial identification often lack sensitivity. Consequently, the diagnosis is mainly based on molecular testing which is critical for species identification. Disc diffusion is a poorly reproducible method for antibiotic susceptibility testing of Bcc when compared to broth microdilution, agar dilution or Etest. Bcc is naturally resistant to many antimicrobialagents including carboxypenicillins, polymyxin, and often, aminoglycosides due to the efflux pump activity. Treatment is often based on antimicrobial susceptibility data. However, trimethoprim-sulfamethoxazole, meropenem, doripenem, doxycycline, minocycline, and ceftazidime have been ...Continue Reading

Citations

Mar 3, 2020·The Pediatric Infectious Disease Journal·Tugba Bedir DemirdagSaliha Kanik Yuksek
Oct 22, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Maroun M Sfeir
Apr 15, 2020·Infection and Immunity·Matthew M Schaefers
Jun 1, 2019·Critical Reviews in Microbiology·Fernando Hayashi Sant'AnnaLuciane M P Passaglia
Feb 12, 2019·Open Forum Infectious Diseases·Georgina Meza-RadillaPaulina Estrada-de Los Santos
Oct 26, 2018·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Sören L BeckerBarbara Gärtner
Oct 22, 2020·Case Reports in Pediatrics·Carlos A CarmonaSarah Marsicek
Jan 9, 2021·Annals of Clinical Microbiology and Antimicrobials·Ming-Chih HoChing-Hsi Hsiao
May 5, 2021·Current Microbiology·Edgard de Freitas ViannaElizabeth Andrade Marques
Jun 8, 2021·Antimicrobial Agents and Chemotherapy·L G KavanaughT R Steck
Sep 26, 2021·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Edgard de Freitas ViannaElizabeth Andrade Marques
May 12, 2020·American Journal of Infection Control·Silvia Maria Dos Santos SaalfeldMaria Cristina Bronharo Tognim

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