Burkholderia gladioli: five year experience in a cystic fibrosis and lung transplantation center

Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society
Marcus P KennedyJames R Yankaskas

Abstract

The impact of infection with Burkholderia gladioli in cystic fibrosis, other chronic airway diseases and immunosuppressed patients is unknown. A six-year retrospective review of all patients with B. gladioli infection was performed in a tertiary referral center with cystic fibrosis and lung transplantation programs. In addition, a targeted survey of all 251 lung transplant recipients was performed. Available B. gladioli isolates were analyzed via pulsed field gel electrophoresis. Thirty-five patients were culture positive for B. gladioli, including 33 CF patients. No bacteremia was identified. Isolates were available in 18 patients and all were genetically distinct. Two-thirds of these isolates were susceptible to usual anti-pseudomonal antibiotics. After acquisition, only 40% of CF patients were chronically infected (> or =2 positive cultures separated by at least 6 months). Chronic infection was associated with resistance to > or =2 antibiotic groups on initial culture and failure of eradication after antibiotic therapy. The impact of acquisition of B. gladioli infection in chronic infection was variable. Three CF patients with chronic infection underwent lung transplantation. One post-transplant patient developed a B. gladio...Continue Reading

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Related Concepts

Infections, Hospital
Pulmonary Cystic Fibrosis
Respiratory Care Units
Retrospective Studies
Lung Transplantation
Field Inversion Gel Electrophoresis
Burkholderia Infections
Burkholderia gladioli

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