Burkholderia gladioli sepsis in newborns

European Journal of Pediatrics
Arzu DursunGonul Tanir

Abstract

Burkholderia gladioli is a rare cause of bacteremia and sepsis in the absence of such predisposing factors as chronic granulomatous disease, cystic fibrosis, and immunosuppression. Little is known about B. gladioli infection in newborns. The aim of this study was to present the features of B. gladioli infection in newborns. Clinicopathological characteristics, patterns of antimicrobial susceptibility, predisposing factors, and outcomes of B. gladioli bloodstream infection were retrospectively analyzed in newborns treated between 2008 and 2011. During the 3-year study period, B. gladioli was isolated from the blood cultures of 14 patients (3.7 per 1,000 admissions). In all, 5 (35.7 %) of the 14 cases had a positive blood culture at the time of initial admission. Primary diagnoses in the neonates were severe major congenital anomalies, congenital leukemia, prematurity with respiratory distress syndrome, pneumonia, and parapneumonic pleural effusion. In total, 10 (71.4 %) of the patients underwent ≥2 invasive procedures. The overall in-hospital mortality rate was 21.4 %, whereas the mortality rate due to B. gladioli infection was 7 %. B. gladioli might be a causative microorganism of both early neonatal and nosocomial sepsis in ne...Continue Reading

References

Feb 1, 1989·Journal of Clinical Microbiology·J C ChristensonD J Brenner
Nov 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J P RossJ I Gallin
Aug 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S Hoare, A J Cant
Nov 14, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M GravesJ M Janda
Dec 24, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J H ShinM H Jeong
Feb 22, 2002·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Caroline Mohr O'Hara, J. Michael Miller
Sep 9, 2005·The Pediatric Infectious Disease Journal·Bobby L BoyantonEdina H Moylett
Mar 20, 2009·Journal of Clinical Microbiology·Christine SegondsGérard Chabanon
Feb 10, 2011·Indian Journal of Medical Microbiology·V GautamP Ray
Jun 15, 2011·American Journal of Infection Control·Cynthia A LuceroArjun Srinivasan
Jul 20, 2011·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Susan A DolanJohn F James

Citations

Apr 9, 2014·The American Journal of Tropical Medicine and Hygiene·Brea D DuvalAlex R Hoffmaster
May 1, 2015·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·F ZhouJ Zhang

Related Concepts

Infections, Hospital
Intensive Care Units, Neonatal
Fungus Drug Sensitivity Tests
Retrospective Studies
Hospital Mortality
Pyemia
Burkholderia Infections
Burkholderia gladioli
Congenital Abnormality
Antibiotics

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.