Burkitt lymphoma- a rare but challenging lymphoma

Best Practice & Research. Clinical Haematology
Carla Casulo, Jonathan W Friedberg

Abstract

Burkitt lymphoma (BL) is a rare, aggressive subtype of non-Hodgkin lymphoma affecting approximately 1500 patients per year. Three forms of BL exist (sporadic, endemic, immunodeficiency associated) and the endemic form was first discovered as being driven by the Epstein Barr virus in areas of the world where malaria is prevalent. BL has the characteristic t8; 14 cytogenetic translocation that leads to constitutive activation of the MYC gene, which drives BL cell division. Therapy of BL has resulted in cure for many patients but significant toxicity and treatment related complications remains problematic in the approach to BL therapy. Treatment options for relapsed and refractory disease remain limited however novel treatments are being studied to block MYC activation, and cold lead to promising options for patients with relapsed and refractory disease.

Citations

Mar 16, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tea UmekRula Zain
Nov 11, 2019·Abdominal Radiology·Abdelrahman K HanafyKhaled M Elsayes
Mar 8, 2020·Current Oncology Reports·Khalil SalehVincent Ribrag
Aug 7, 2020·Journal of the National Comprehensive Cancer Network : JNCCN·Kimberly DaviesDeborah A Freedman-Cass
Nov 23, 2020·International Journal of Clinical Practice·Ying LiuZhi-Gui Zeng
Mar 21, 2020·American Journal of Ophthalmology Case Reports·Matthew S WiederSaadia Rashid
Mar 20, 2021·Scientific Reports·Morten P OksvoldThea Kristin Våtsveen
Jul 2, 2021·Infectious Agents and Cancer·Francisco AguayoRancés Blanco
Jul 27, 2021·Clinical Case Reports·Nahal AzimiNeda Kardouni Khoozestani
Aug 28, 2021·Biomedicines·Ekaterina Mikhailovna StasevichAnton Markovich Schwartz
Sep 25, 2021·Frontiers in Oncology·Irene BagaloniPier Paolo Piccaluga

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