Burkitt transformation of mantle cell lymphoma

Leukemia & Lymphoma
Christopher L FeltenLawrence Hertzberg

Abstract

The associated poor prognosis and potentially aggressive behavior of mantle cell lymphoma and its blastoid variants make differentiation from other non-Hodgkin B-cell lymphomas especially important. We present a case of mantle cell lymphoma with a marked leukemic component, which demonstrated both a typical nodular mantle cell pattern and Burkitt lymphoma within a single lymph node removed at the time of splenectomy. The presence of CD5, CD10, and Bcl-1 co-expression by immunohistochemistry and detectable t(11;14) and cMYC gene rearrangement by FISH analyses in the Burkitt region support a transformation of mantle cell lymphoma over a concomitant malignancy. A limited number of mantle cell lymphomas demonstrating dual t(11;14) and chromosome 8q24 cMYC gene rearrangements have been previously reported in the literature. They demonstrate an extremely aggressive course with a very poor prognosis. Although the accelerated terminal phase of this patient's clinical course mirrors these previous published cases; none have described the combined morphologic and immunophenotypic features of Burkitt lymphoma reported here. This case provides further support for the aggressive nature of these lymphomas and demonstrates the utility of flow...Continue Reading

References

Dec 10, 1999·American Journal of Clinical Pathology·C W LinM Albitar
Jul 27, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·D S ViswanathaC P Leith
Nov 28, 2001·British Journal of Haematology·U N VaishampayanM Palutke
Dec 14, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Suyang HaoL Jeffrey Medeiros

❮ Previous
Next ❯

Citations

Jul 19, 2006·Virchows Archiv : an International Journal of Pathology·Ioannis KostopoulosLorenzo Leoncini
Apr 10, 2008·Leukemia & Lymphoma·Kavita ReddyBruno Dipasquale
Dec 24, 2005·Pathology·Lynda J Campbell
Dec 2, 2010·Blood·Sietse M AukemaPhilip M Kluin
Aug 31, 2020·Hematology/oncology Clinics of North America·Kevin WangSelina Chen-Kiang

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

CNS Lymphoma

In CNS lymphoma, cancerous cells from lymph tissues or other parts of the body form tumors in the brain and/or spinal cord. Here is the latest research on this rare non-Hodgkin lymphoma.