Burmese injecting drug users in Yunnan play a pivotal role in the cross-border transmission of HIV-1 in the China-Myanmar border region

Virulence
Xin ChenYong-Tang Zheng

Abstract

Injecting drug users (IDUs) are the major risk group for HIV-1 infection in the China-Myanmar border area. There are a large number of Burmese IDUs living in Yunnan (Yunnan-mIDUs) who might be associated with the cross-border transmission of HIV-1. From 2010 to 2013, 617 Yunnan-mIDUs were recruited from three counties of Yunnan, 19.0% of whom were detected to be HIV-1 positive by serological testing. Partial HIV-1 p17, pol, vif-env, and env genes were amplified from the positive samples and were sequenced. Phylogenetic and HIV-1 subtyping analyses revealed that HIV-1 recombinant forms (RFs), including RF_BC (36.4%), RF_01BC (26.1%), RF_01C (9.1%) and RF_01B (1.1%), were predominant among this cohort. Of the identified HIV-1 strains, 14.8%, 9.1% and 3.4% belonged to subtype C, CRF01_AE and subtype B, respectively. Transmission cluster analysis showed that sequences from the Yunnan-mIDUs formed transmission clusters not only with those from Burmese IDUs but also with those from Chinese IDUs, indicating that Yunnan-mIDUs might acquire HIV-1 infection from or spread HIV-1 to both Burmese and Chinese IDUs. Phylogeographic analyses revealed three cross-border transmission patterns associated with Yunnan-mIDUs, in which Yunnan-mIDUs s...Continue Reading

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Citations

Dec 13, 2019·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Xu WangWen-Zhe Ho
Aug 18, 2020·AIDS Research and Human Retroviruses·Ying-Na XieXin Chen
Apr 2, 2020·Virologica Sinica·Xin ChenYong-Tang Zheng
May 6, 2020·Infection and Drug Resistance·Mei YeYong-Tang Zheng
Jul 31, 2019·BMC Infectious Diseases·Min ChenManhong Jia
May 7, 2019·Frontiers in Microbiology·Mei YeYong-Tang Zheng
Dec 9, 2020·AIDS Research and Human Retroviruses·Ying-Na XieHong Li

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Datasets Mentioned

BETA
KX988316
KX988415
MF000419
MF000429

Methods Mentioned

BETA
PCR

Software Mentioned

Tracer
BEAUti
Tree Annotator
FigTree
BEAST
Simplot
MEGA7
Cluster Picker
Recombinant Identification Program

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