Burn: An inflammatory process

Pathologie-biologie
F RavatN Sens

Abstract

Thermal injury induce a two-phase inflammatory response: first, a pro-inflammatory status, resulting in a systemic inflammatory response syndrome, then an anti-inflammatory phase characterized by a profound defect in cellular-mediated immunity. This inflammatory reaction proceeds from complex phenomenons in whom many cellular elements are involved (macrophage is the central one) and very complex molecular products interact (especially cytokines). These phenomenons promote significant physiopathologic consequences, especially on cardiovascular homeostasis and endothelial permeability, that lower the prognosis. The inflammatory reaction can be modified, enhanced or maintained by adverse events (i.e. infection) resulting in degradation of clinical situation. Despite a better comprehension of the phenomenons underlying this inflammatory process, diagnosis or therapeutic applications are at that time disappointing.

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Citations

Sep 10, 2016·Tissue Engineering. Part B, Reviews·Dorothée GirardAlexis Desmoulière
Feb 16, 2017·Journal of Burn Care & Research : Official Publication of the American Burn Association·Ruiqi LiuYing Cen
May 18, 2016·Journal of Burn Care & Research : Official Publication of the American Burn Association·Colton B NielsonJohn G Wood
Feb 9, 2018·Inflammation·Huda O AbuBakrAmanallah El-Bahrawy
Mar 31, 2019·Journal of Burn Care & Research : Official Publication of the American Burn Association·Ruiqi LiuYing Cen
Dec 12, 2020·Journal of Burn Care & Research : Official Publication of the American Burn Association·David M BurmeisterJeffrey W Shupp
Jun 15, 2021·BioMed Research International·Xinheng LiuHongmian Li
Aug 27, 2021·Experimental and Molecular Pathology·Sarah KerschbaumThomas Czerny

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