Burn-associated bone disease in sheep: roles of immobilization and endogenous corticosteroids

The Journal of Burn Care & Rehabilitation
G L KleinD L Traber

Abstract

To determine the role of immobilization in the pathogenesis of burn-associated bone disease, we selected the sheep as a model to study the effects of burn injury compared with a sham-burned control group. Seven of the sheep were subjected to controlled 40% flame burn, and seven underwent anesthesia with arterial and venous cannulation but without burn. After labeling newly formed bone with tetracycline and calcein, the sheep were killed 2 weeks after burn or sham burn, and the iliac crest and lumbar vertebrae were analyzed for histomorphometry. Analysis failed to demonstrate a significant reduction of bone formation rate in the burned sheep. Osteoid area and surface and osteoblast surface, which correlated significantly with bone formation rate (r = 0.49, p < 0.025), were reduced in the burned sheep. Results suggest that immobilization may play a primary role in the pathogenesis of burn-associated bone disease, but the presence of differences in other histomorphometric features indicates the bone disease is multifactorial.

Citations

Oct 16, 2003·The Journal of Surgical Research·Linda S EdelmanStephen E Morris
Sep 23, 2003·The Journal of Burn Care & Rehabilitation·Theresa MayesGlenn D Warden
Sep 16, 2008·Annals of Surgery·Marc G JeschkeDavid N Herndon
Jul 27, 2011·PloS One·Marc G JeschkeDavid N Herndon
Sep 18, 2007·Burns : Journal of the International Society for Burn Injuries·Gordon L KleinRoger J Bick
Jun 4, 2004·Journal of the American Dietetic Association·Michele M GottschlichGlenn D Warden
Mar 27, 2001·The Journal of Surgical Research·T UtsunomiyaF Suzuki
Jul 13, 2016·Journal of Burn Care & Research : Official Publication of the American Burn Association·Matthew HoscheitJohn Callaci
Aug 13, 2008·Journal of Burn Care & Research : Official Publication of the American Burn Association·Berrin LeblebiciMehmet A Haberal

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