Burn-induced subepicardial injury in frog heart: a simple model mimicking ST segment changes in ischemic heart disease

The Journal of Veterinary Medical Science
Itsuro Kazama

Abstract

To mimic ischemic heart disease in humans, several animal models have been created, mainly in rodents by surgically ligating their coronary arteries. In the present study, by simply inducing burn injuries on the bullfrog heart, we reproduced abnormal ST segment changes in the electrocardiogram (ECG), mimicking those observed in ischemic heart disease, such as acute myocardial infarction and angina pectoris. The "currents of injury" created by a voltage gradient between the intact and damaged areas of the myocardium, negatively deflected the ECG vector during the diastolic phase, making the ST segment appear elevated during the systolic phase. This frog model of heart injury would be suitable to explain the mechanisms of ST segment changes observed in ischemic heart disease.

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Citations

Mar 6, 2018·The Journal of Veterinary Medical Science·Nobuaki KonItsuro Kazama
Dec 13, 2019·The Journal of Veterinary Medical Science·Itsuro KazamaMayu Suzuki
Oct 25, 2016·The Journal of Veterinary Medical Science·Itsuro Kazama
Feb 21, 2019·SAGE Open Medical Case Reports·Itsuro Kazama, Toshiyuki Nakajima
Feb 23, 2021·The Journal of Veterinary Medical Science·Itsuro Kazama
Oct 19, 2021·The Journal of Veterinary Medical Science·Rei Na YeohItsuro Kazama

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