Abstract
To mimic ischemic heart disease in humans, several animal models have been created, mainly in rodents by surgically ligating their coronary arteries. In the present study, by simply inducing burn injuries on the bullfrog heart, we reproduced abnormal ST segment changes in the electrocardiogram (ECG), mimicking those observed in ischemic heart disease, such as acute myocardial infarction and angina pectoris. The "currents of injury" created by a voltage gradient between the intact and damaged areas of the myocardium, negatively deflected the ECG vector during the diastolic phase, making the ST segment appear elevated during the systolic phase. This frog model of heart injury would be suitable to explain the mechanisms of ST segment changes observed in ischemic heart disease.
References
Apr 1, 1979·Circulation Research·M A PfefferE Braunwald
May 1, 1991·The American Journal of Physiology·J M PfefferE Braunwald
Sep 1, 1981·Circulation Research·P J FletcherE Braunwald
Feb 19, 1999·Lancet·D M Lloyd-JonesD Levy
Dec 22, 1999·The American Journal of Physiology·R W Fasciano, L Tung
Mar 23, 2000·Cardiovascular Research·A G Kléber
Dec 12, 2001·Journal of the American College of Cardiology·J J BaileyM Hodges
Feb 5, 2002·Advances in Physiology Education·S Yoshida
Aug 23, 2002·Molecular and Cellular Biochemistry·Elena C LascanoHéctor F del Valle
Mar 26, 2003·Cardiovascular Research·William FullerMichael J Shattock
Oct 1, 1962·Circulation·E PAGE
Apr 15, 1964·The Japanese Journal of Physiology·H IRISAWA, M KOBAYASHI
Feb 21, 2009·Circulation·Galen S WagnerUNKNOWN Heart Rhythm Society
May 9, 2009·Cardiovascular Research·José Luis Martín-VenturaJesús Egido
Mar 16, 2011·Journal of Biomedicine & Biotechnology·Carlos ZaragozaJesus Egido
Dec 4, 2012·Interactive Cardiovascular and Thoracic Surgery·Maria MunzArtur P Águas
Citations
Mar 6, 2018·The Journal of Veterinary Medical Science·Nobuaki KonItsuro Kazama
Dec 13, 2019·The Journal of Veterinary Medical Science·Itsuro KazamaMayu Suzuki
Oct 25, 2016·The Journal of Veterinary Medical Science·Itsuro Kazama
Feb 21, 2019·SAGE Open Medical Case Reports·Itsuro Kazama, Toshiyuki Nakajima
Feb 23, 2021·The Journal of Veterinary Medical Science·Itsuro Kazama
Oct 19, 2021·The Journal of Veterinary Medical Science·Rei Na YeohItsuro Kazama