Burn injury induces an early activation response by lymph node CD4+ T cells

Shock
Elizabeth M PurcellJames A Lederer

Abstract

Several reports have shown that burn injury primes the immune system for an early and vigorous proinflammatory CD4 T cell response, suggesting that injury might signal CD4 T cell activation. We addressed this possibility by investigating changes in CD4 T cell activation marker expression, proliferation, and T cell receptor (TCR) usage at several early time points after burn injury. Using a sensitive flow cytometry approach to measure changes in the expression of Ki-67 antigen, a nuclear protein detected only in proliferating cells, we observed an early burst of proliferation by lymph node, but not spleen, CD4 T cells 12 h after burn injury. In contrast, mice that were treated with the bacterial superantigen staphylococcal enterotoxin B (SEB) as a positive control for in vivo T cell activation did not show this early proliferation. Instead, we observed a significant increase in proliferating lymph node and spleen CD4 and CD8 T cells by 3 days after SEB treatment. Burn injury induced higher cell surface CD25 and CD152 expression on lymph node CD4 T cells, whereas SEB treatment increased CD25 and CD69 expression on CD4 and CD8 T cells. Finally, we found that burn injury induced a proliferative response at 12 h by an oligoclonal su...Continue Reading

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Citations

Nov 20, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Ying ZhangZhi-yong Sheng
Mar 5, 2008·Shock·Kiho ChoDavid G Greenhalgh
Oct 5, 2010·Journal of Leukocyte Biology·Malcolm P MacConmaraJames A Lederer
Jun 2, 2012·Journal of Leukocyte Biology·Veit M StoeckleinJames A Lederer
Dec 10, 2009·World Journal of Gastroenterology : WJG·Chong LiuShu-Wen Zhang
Sep 27, 2007·International Journal of Biological Sciences·Nadeem Fazal, Walid M Al-Ghoul
Jun 18, 2015·Expert Opinion on Therapeutic Targets·Maximilian WenigerIrshad H Chaudry
Dec 1, 2007·Injury·Mashkoor A ChoudhryIrshad H Chaudry
Nov 21, 2007·Brain, Behavior, and Immunity·Junping XinKathryn J Jones
Jan 15, 2014·Innate Immunity·Meenakshi RaniMartin G Schwacha
Jun 3, 2017·PloS One·Meenakshi Rani, Martin G Schwacha
May 15, 2007·Journal of Applied Physiology·Dan Michael CooperFrank Zaldivar
Nov 23, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jacqueline UnsingerThomas A Ferguson
Apr 10, 2021·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Ruth HimmelsbachDietrich A Ruess

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