PMID: 7542580Jan 1, 1995Paper

Bursal antisteroidogenic peptide alters the activity of steroidogenic enzymes in chicken granulosa cells

Domestic Animal Endocrinology
C E DeanB M Hargis

Abstract

We have previously reported that a peptide from chicken bursa of Fabricius, bursal antisteroidogenic peptide (BASP), inhibits luteinizing hormone-stimulated progesterone biosynthesis by chicken ovarian granulosa cells. The objective of this study was to determine the site(s) of BASP inhibition within the steroidogenic pathway of chicken granulosa cells. The effects of BASP on key steroidogenic enzymes, including adenylyl cyclase (AC), phosphodiesterase, the cholesterol side-chain cleavage enzyme complex and 3 beta-hydroxysteroid dehydrogenase were determined. Luteinizing hormone (10 ng/tube) stimulated a fivefold increase in granulosa cell progesterone production that was inhibited by BASP (0.06, 0.12 or 0.25 bursal equivalents) in a dose-dependent manner. Luteinizing hormone stimulated a sixfold increase in cyclic 3',5'-adenosine monophosphate (cAMP) formation, and this increase was potentiated by BASP in a dose-dependent manner. In addition, BASP stimulated cAMP formation in the absence of luteinizing hormone without affecting progesterone production. The AC activator forskolin (0.1 mM) stimulated a 4.5-fold increase in progesterone synthesis, which was inhibited by BASP. In the presence of forskolin. BASP increased cAMP form...Continue Reading

References

May 1, 1982·Poultry Science·M M MashalyD R Hagen
Jul 1, 1994·Comparative Biochemistry and Physiology. Pharmacology, Toxicology and Endocrinology·J A ByrdB M Hargis

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Citations

Mar 20, 2003·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·R W MooreB M Hargis

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