Burst discharges in neurons of the thalamic reticular nucleus are shaped by calcium-induced calcium release

Cell Calcium
Philippe CoulonHans-Christian Pape

Abstract

The nucleus reticularis thalami (NRT) is a layer of inhibitory neurons that surrounds the dorsal thalamus. It appears to be the 'pacemaker' of certain forms of slow oscillations in the thalamus and was proposed to be a key determinant of the internal attentional searchlight as well as the origin of hypersynchronous activity during absence seizures. Neurons of the NRT exhibit a transient depolarization termed low threshold spike (LTS) following sustained hyperpolarization. This is caused by the activation of low-voltage-activated Ca2+ channels (LVACC). Although the role of these channels in thalamocortical oscillations was studied in great detail, little is known about the downstream intracellular Ca2+ signalling pathways and their feedback onto the oscillations. A signalling triad consisting of the sarco(endo)plasmic reticulum calcium ATPase (SERCA), Ca2+ activated K+ channels (SK2), and LVACC is active in dendrites of NRT neurons and shapes rhythmic oscillations. The aim of our study was to find out (i) if and how Ca2+-induced Ca2+ release (CICR) via ryanodine receptors (RyR) can be evoked in NRT neurons and (ii) how the released Ca2+ affects burst activity. Combining electrophysiological, immunohistochemical, and two-photon C...Continue Reading

References

Jan 1, 1989·Annual Review of Neuroscience·R Y Tsien
Jul 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·F Crick
Dec 1, 1994·The Journal of General Physiology·J García, K G Beam
Nov 1, 1994·Neuroscience·P Kostyuk, A Verkhratsky
Oct 29, 1993·Science·M SteriadeT J Sejnowski
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·R Llinás, U Ribary
Jan 1, 1997·Annual Review of Neuroscience·D A McCormick, T Bal
Jan 29, 2000·Brain Research. Molecular Brain Research·E M TalleyD A Bayliss
May 4, 2002·Nature Reviews. Neuroscience·Vincenzo Crunelli, Nathalie Leresche
Jun 13, 2002·The European Journal of Neuroscience·Sven MeuthThomas Budde
Aug 26, 2003·Nature Neuroscience·Ryohei YasudaKarel Svoboda
Feb 11, 2004·Pflügers Archiv : European journal of physiology·Hans-Christian PapeThomas Budde
Feb 27, 2004·American Journal of Physiology. Cell Physiology·Takashi Murayama, Yasuo Ogawa
Sep 21, 2004·Nature Reviews. Neuroscience·Martin Stocker
Mar 24, 2005·Progress in Neurobiology·Pablo Fuentealba, Mircea Steriade
Sep 9, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Trevor A RichterLeo P Renaud
May 13, 2006·Cell Calcium·Christian D WilmsJens Eilers
Jun 17, 2006·Cell Calcium·Vincenzo CrunelliStuart W Hughes
Apr 28, 2007·The Journal of Physiology·Sang-Hun LeeCharles L Cox

❮ Previous
Next ❯

Citations

Sep 14, 2011·Pflügers Archiv : European journal of physiology·Philippe CoulonHans-Christian Pape
Apr 17, 2013·Pflügers Archiv : European journal of physiology·James HydeEdgar Garcia-Rill
Nov 12, 2013·Trends in Neurosciences·Simone AstoriAnita Lüthi
Apr 15, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Adam C Errington, William M Connelly
Feb 21, 2013·Annals of Neurology·Sven G MeuthHans-Christian Pape
Nov 6, 2013·The European Journal of Neuroscience·Philippe AlixVincent Seutin
Jan 29, 2010·The European Journal of Neuroscience·Vladan RankovicThomas Budde
Mar 24, 2016·Nature·Michael F WellsMichael M Halassa
Apr 5, 2016·Cell Calcium·Christina NeyerPhilippe Coulon
Oct 7, 2015·Frontiers in Computational Neuroscience·Daniel H ElijahMarcelo A Montemurro
Dec 9, 2010·Channels·Stuart M Cain, Terrance P Snutch
Oct 20, 2011·Progress in Neurobiology·Henry C Tuckwell
Mar 19, 2014·Proceedings of the National Academy of Sciences of the United States of America·Gesche BornMarkus Missler
Oct 9, 2015·PloS One·Eric AzabouUNKNOWN Groupe d'Explorations Neurologiques en Réanimation (GENER)
Mar 5, 2016·The Journal of Physiology·Denise KohmannHans-Christian Pape
Sep 20, 2018·Journal of Neurophysiology·Menahem Segal
Aug 31, 2013·Journal of Applied Physiology·James HydeEdgar Garcia-Rill
Apr 18, 2014·Journal of Neurophysiology·Vladimir Marlinski, Irina N Beloozerova
Oct 25, 2014·Journal of Neurophysiology·Nicholas D VespriniGaynor E Spencer
Aug 27, 2015·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Sirawaj Itthipuripat, John T Serences
Feb 22, 2018·Biomolecules & Therapeutics·Ji-Woon KimChan Young Shin
Jun 14, 2016·Neural Plasticity·Christoph LindemannIleana L Hanganu-Opatz
Nov 27, 2020·Psychopharmacology·María Celeste Rivero-EchetoFrancisco J Urbano
Dec 29, 2020·Neurobiology of Disease·Chinnasamy DhanalakshmiMark A Nelson
Jul 26, 2019·Neurobiology of Disease·Udaiyappan JanakiramanMark A Nelson
Aug 17, 2020·Journal of Neuroscience Methods·Brice De La CrompeIlka Diester

❮ Previous
Next ❯

Related Concepts

Related Feeds

Absence Epilepsy

Absence epilepsy is a common seizure disorder in children which can produce chronic psychosocial sequelae. Discover the latest research on absence epilepsies here.