Burst Firing and Spatial Coding in Subicular Principal Cells

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Jean Simonnet, Michael Brecht

Abstract

The subiculum is the major output structure of the hippocampal formation and is involved in learning and memory as well as in spatial navigation. Little is known about how neuronal diversity contributes to function in the subiculum. Previously, in vitro studies have identified distinct bursting patterns in the subiculum. Here, we asked how burst firing is related to spatial coding in vivo Using juxtacellular recordings in freely moving male rats, we studied the bursting behavior of 102 subicular principal neurons and distinguished two populations: sparsely bursting (∼80%) and dominantly bursting neurons (∼20%). These bursting behaviors were not linked to anatomy: both cell types were found all along the proximodistal and radial axes of the subiculum and all identified cells were pyramidal neurons. However, the distinct burst firing patterns were related to functional differences: the activity of sparsely bursting cells showed a stronger spatial modulation than the activity of dominantly bursting neurons. In addition, all cells classified as boundary cells were sparsely bursting cells. In most sparsely bursting cells, bursts defined sharper firing fields and carried more spatial information than isolated spikes. We conclude that...Continue Reading

Citations

Sep 26, 2020·Frontiers in Neuroscience·Shin YanagiharaKazuo Okanoya
Feb 23, 2020·Cell Reports·Jason S BantLisa M Giocomo
Mar 5, 2021·Reviews in the Neurosciences·Maxime Lévesque, Massimo Avoli
Mar 12, 2021·Science Advances·Takuma KitanishiKenji Mizuseki
May 24, 2021·Neural Networks : the Official Journal of the International Neural Network Society·Shiming SongQiang Yu

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