Burst & High-Frequency Spinal Cord Stimulation Differentially Effect Spinal Neuronal Activity After Radiculopathy

Annals of Biomedical Engineering
Alexander R KentBeth A Winkelstein

Abstract

Although burst and high-frequency (HF) spinal cord stimulation (SCS) relieve neuropathic pain, their effects on neuronal hyperexcitability have not been compared. Specifically, it is unknown how the recharge components of burst SCS-either actively balanced or allowed to passively return-and/or different frequencies of HF SCS compare in altering neuronal activity. Neuronal firing rates were measured in the spinal dorsal horn on day 7 after painful cervical nerve root compression in the rat. Motor thresholds (MTs) and evoked neuronal recordings were collected during noxious stimuli before (baseline) and after delivery of SCS using different SCS modes: 10 kHz HF, 1.2 kHz HF, burst with active recharge, or burst with passive recharge. Spontaneous firing rates were also evaluated at baseline and after SCS. The average MT for 10 kHz SCS was significantly higher (p < 0.033) than any other mode. Burst with passive recharge was the only SCS mode to significantly reduce evoked (p = 0.019) and spontaneous (p = 0.0076) firing rates after noxious pinch. This study demonstrates that HF and burst SCS have different MTs and effects on both evoked and spontaneous firing rates, indicating they have different mechanisms of providing pain relief. ...Continue Reading

References

Aug 29, 2009·The Journal of Pain : Official Journal of the American Pain Society·Alban Latremoliere, Clifford J Woolf
Apr 21, 2010·Neurosurgery·Dirk De RidderTomas Menovsky
Nov 17, 2011·Current Pain and Headache Reports·Aaron K ComptonSalim M Hayek
Jul 1, 1999·Neuromodulation : Journal of the International Neuromodulation Society·B Linderoth, R D Foreman
Dec 21, 2012·Neuromodulation : Journal of the International Neuromodulation Society·Jason M CuellarJoseph F Antognini
Mar 26, 2013·Neuroscience Letters·Nathan D CrosbyBeth A Winkelstein
Mar 25, 2014·Neuromodulation : Journal of the International Neuromodulation Society·Rurong TangRobert D Foreman
Mar 25, 2014·Neuromodulation : Journal of the International Neuromodulation Society·Cecile C de VosDirk de Ridder
Aug 26, 2014·Neuromodulation : Journal of the International Neuromodulation Society·Nathan D CrosbyBeth A Winkelstein
Mar 25, 2015·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Claudia M CampbellPaul J Christo
Apr 17, 2015·Neuromodulation : Journal of the International Neuromodulation Society·Peter CourtneyKristina Davis
Sep 8, 2015·Neuromodulation : Journal of the International Neuromodulation Society·Zhiyang SongBengt Linderoth
Feb 15, 2017·Neuromodulation : Journal of the International Neuromodulation Society·Thomas M KinfeThomas L Yearwood
Sep 30, 2017·Neuromodulation : Journal of the International Neuromodulation Society·Timothy DeerDerron Wilson
Dec 9, 2017·Neuromodulation : Journal of the International Neuromodulation Society·Simon J ThomsonMichael Moffitt
Oct 18, 2018·Neuromodulation : Journal of the International Neuromodulation Society·Laura DemartiniMatteo L G Leoni

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Citations

Mar 24, 2020·Neuromodulation : Journal of the International Neuromodulation Society·Timothy R DeerKrishnan V Chakravarthy
May 15, 2020·Postgraduate Medicine·Lonne Heijmans, Elbert A Joosten
Jun 4, 2020·Bioelectronic Medicine·Marco Capogrosso, Scott F Lempka

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