Buserelin. A review of its pharmacodynamic and pharmacokinetic properties, and clinical profile

Drugs
R N BrogdenA Ward

Abstract

The gonadotrophin releasing hormone (GnRH) [luteinising hormone-releasing hormone (LHRH); gonadorelin] agonist buserelin is a promising new agent in the treatment of a variety of disorders in gynaecology and andrology, paediatrics and oncology. While a single dose of buserelin stimulates the release of pituitary gonadotrophins, multiple doses produce reversible pituitary desensitisation, and this specific blockade of gonadotrophin support to the gonads provides the basis for the drug's efficacy in conditions dependent on sex hormone secretion. Thus, buserelin provides comparable efficacy to orchidectomy or high dose estrogens in the treatment of hormone-sensitive prostate cancer and exhibits a lower incidence of adverse effects. During the early phase of treatment it may be particularly useful in combination with antiandrogens. Buserelin also appears promising in hormone-sensitive premenopausal breast cancer. Extensive studies have proven the value of buserelin in endometriosis, where it produces a transient remission with gradual recurrence of the disease on cessation of treatment. Surgical intervention is necessary in severe disease after buserelin-induced involution of the lesions. In patients with uterine leiomyoma, prelimi...Continue Reading

Citations

Oct 1, 1996·European Journal of Drug Metabolism and Pharmacokinetics·N HeinrichH Berger
Dec 24, 1997·Journal of Pediatric Endocrinology & Metabolism : JPEM·M C AlbanoB B Mendonca
Apr 23, 2013·Case Reports in Obstetrics and Gynecology·Djavid I AlleemudderSallie Davies
Sep 2, 2000·Journal of Pediatric Endocrinology & Metabolism : JPEM·N LahlouM Roger
Sep 4, 2018·Expert Opinion on Drug Delivery·Wisam Al BakriZhen Yang
Jun 19, 2002·Proceedings of the National Academy of Sciences of the United States of America·Britta WlotzkaSven Klussmann
Sep 1, 1994·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·H A Van Leusden
Mar 21, 2019·International Journal of Molecular Sciences·Kok-Yong Chin, Soelaiman Ima-Nirwana

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