PMID: 2506941Jan 1, 1989Paper

Buserelin in the treatment of prostatic cancer

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
F Roila

Abstract

Buserelin is a synthetic gonadotropin-releasing hormone (GnRH) analog which is more potent than natural GnRH. Prolonged administration of the drug produces, after a short phase of stimulation, a selective and durable inhibition of secretion of pituitary gonadotropins, resulting in medical castration. In pilot and controlled studies buserelin shows a response rate that is similar to that of diethylstilbestrol or orchiectomy in the palliative treatment of advanced prostatic cancer, but larger and better designed studies are needed before reaching definitive conclusions about the duration of response and survival. The most common adverse effects of buserelin are loss of libido and/or impotence, hot flushes and possible flare-up of prostatic carcinoma symptoms in the first week of therapy. The combination of buserelin with an antiandrogen could avoid the flare syndrome; whether the combination has advantages compared to administration of buserelin alone requires confirmation from the large randomized studies still in progress.

References

Jan 1, 1987·Scandinavian Journal of Urology and Nephrology·F PeterssonE Varenhorst
Jan 1, 1986·Cancer Chemotherapy and Pharmacology·J H WaxmanP J Magill
Jan 1, 1987·European Journal of Clinical Pharmacology·C LarsenV Malerczyk
Jan 1, 1983·The Prostate·V BorgmannM Schmidt-Gollwitzer
Nov 15, 1984·The New England Journal of Medicine·UNKNOWN Leuprolide Study Group

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Citations

Jan 12, 2001·Journal of Clinical Gastroenterology·J R Pisegna
Nov 9, 2004·Clinical Pharmacokinetics·René SeverijnenGer Bongaerts

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