Bushen-Yizhi formula ameliorates cognitive dysfunction through SIRT1/ER stress pathway in SAMP8 mice

Oncotarget
Shi-Jie ZhangQi Wang

Abstract

The Chinese formula Bushen-Yizhi (BSYZ) has been reported to ameliorate cognitive dysfunction. However the mechanism is still unclear. In this study, we employ an aging model, SAMP8 mice, to explore whether BSYZ could protect dementia through SIRT1/endoplasmic reticulum (ER) stress pathway. Morris water maze and the fearing condition test results show that oral administration of BSYZ (1.46 g/kg/d, 2.92 g/kg/d and 5.84 g/kg/d) and donepezil (3 mg/kg/d) shorten the escape latency, increase the crossing times of the original position of the platform and the time spent in the target quadrant, and increase the freezing time. BSYZ decreases the activity of acetylcholinesterase (AChE), and increases the activity of choline acetyltransferase (ChAT) and the concentration of acetylcholine (Ach) in both hippocampus and cortex. In addition, western blot results (Bcl-2, Bax and Caspase-3) and TUNEL staining show that BSYZ prevents neuron from apoptosis, and elevates the expression of neurotrophic factors, including nerve growth factor (NGF), postsynapticdensity 95 (PSD95) and synaptophysin (SYN), in both hippocampus and cortex. BSYZ also increases the protein expression of SIRT1 and alleviates ER stress-associated proteins (PERK, IRE-1α, eI...Continue Reading

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Citations

Jun 27, 2020·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Hye Jin HeoChi Dae Kim
Nov 16, 2018·International Journal of Molecular Medicine·Hang YuMingming Dai
May 16, 2019·The Journal of Physiological Sciences : JPS·Dafeng BaiYan Cui
Jun 19, 2018·Molecular Neurobiology·S VelaMaría J Ramirez
Jan 29, 2019·Neural Regeneration Research·Yu-Min XuWei-Xiong Liang
Apr 21, 2020·Journal of Alzheimer's Disease : JAD·Bo LiuJing-Shan Shi
Sep 19, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Yousheng MoQi Wang

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Methods Mentioned

BETA
acetylation
protein assay
electrophoresis

Software Mentioned

SPSS

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