PMID: 9193169Jan 1, 1997Paper

Buspirone, a serotonergic 5-HT1A agonist, is active in cerebellar ataxia. A new fact in favor of the serotonergic theory of ataxia

Progress in Brain Research
P TrouillasP Adeleine

Abstract

We have previously proposed a serotonergic hypothesis for cerebellar ataxia and mentioned that the levorotatory form of 5-hydroxytryptophan, a serotonin precursor, is partially active in subtypes of cerebellar ataxia, including cerebellar cortical atrophy (CCA). It has been demonstrated that 5-HT1A serotonergic receptors play an important role in the control of Purkinje cells discharges and in the inhibition of the release of glutamate by cerebellar glutamatergic terminals. To test further the serotonergic hypothesis of cerebellar ataxia, we administered buspirone, a 5-HT1A agonist usable in human medicine, in a randomized double blind drug placebo trial for 4 months. Nineteen patients with CCA were included; nine patients were given placebo and 10 Buspirone, at the mean dose of 0.69 mg/kg. The evaluation of ataxia was based on a static and a kinetic ataxia scale, fully quantitative measures and the evaluation of the sway path and area at posturography. At 4 months, a significant effect of buspirone was observed for drug induced gains of the kinetic score, two items of the static score, and the maximum duration of standing upright with feet together. These results indicate that a novel chemical therapeutic approach is possible ...Continue Reading

Citations

Apr 16, 2002·Psychiatry and Clinical Neurosciences·Asako TakeiKunio Tashiro
Oct 23, 2013·Pflügers Archiv : European journal of physiology·Chang-Zheng ZhangJian-Jun Wang
Nov 19, 2014·Neurodegenerative Disease Management·Tracy M JonesTheresa A Zesiewicz
Sep 9, 2005·The Cerebellum·Asako TakeiHidenao Sasaki
Apr 2, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Olivier RascolUNKNOWN MSA-FLUO Study Group

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