Buspirone enhances immobility in the forced swim test in mice

Pharmacology, Biochemistry, and Behavior
Y Kitamura, T Nagatani

Abstract

We studied the effects of buspirone and 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) on duration of immobility in mice in the forced swim test. Buspirone [3-10 mg/kg, intraperitoneally (IP)] potently and dose dependently increased the duration of immobility in mice. In contrast, following a single dose of 8-OH-DPAT (1-3 mg/kg, IP), there was a dose-dependent decrease in the duration of immobility. Pretreatment with the 5-HT synthesis inhibitor p-chlorophenylalanine (200 mg/kg, IP, 3 days before further drug treatment) did not alter the effects of buspirone or 8-OH-DPAT. The increase in the duration of immobility induced by buspirone (3 mg/kg, IP) was blocked by NAN-190 [1-(2-methoxyphenyl)-4-(4-[2-phthalimido]butyl)-piperazine hydrobromide, 1 mg/kg, IP], a postsynaptic 5-HT1A receptor antagonist. However, the effect of 8-OH-DPAT (1 mg/kg, IP) was not blocked by NAN-190 (1 mg/kg, IP). The effect of buspirone (3 mg/kg, IP) was blocked by apomorphine (0.3 mg/kg, IP), a dopamine receptor agonist. Based on the results of this study, it is suggested that the effects of buspirone and of 8-OH-DPAT on immobility in the forced swim test may occur through different mechanisms.

References

Oct 29, 1991·European Journal of Pharmacology·Y ClaustreB Scatton
Jan 17, 1990·European Journal of Pharmacology·L CervoR Samanin
Jun 12, 1990·European Journal of Pharmacology·I van WijngaardenW Soudijn
Sep 22, 1989·European Journal of Pharmacology·W KostowskiR Stefański
Mar 1, 1986·Pharmacology, Biochemistry, and Behavior·J M Witkin, J E Barrett
Dec 1, 1987·Japanese Journal of Pharmacology·H ShimizuJ Katsube
Jan 1, 1985·Journal of Neural Transmission·S Hjorth
Jan 1, 1971·Annual Review of Pharmacology·M W Anders
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·M RuatJ C Schwartz
Mar 1, 1993·British Journal of Pharmacology·G P LuscombeD J Heal

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Citations

Jun 19, 1998·Pharmacology, Biochemistry, and Behavior·A BessonJ Fialip
Sep 18, 2004·Brain Research·Andréa Dias Elpo ZomkowskiAna Lúcia Severo Rodrigues
May 6, 2010·Journal of Ethnopharmacology·Geun Hee SeolSun Seek Min
Sep 9, 2017·Chronic Stress·Kaziya M LeeKaren K Szumlinski
Dec 22, 2017·ACS Chemical Neuroscience·Magdalena Jastrzębska-WięsekAdrian Newman-Tancredi

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