Busulfan-Induced Lung Injury in Pediatric Oncology Patients-Review of the Literature with an Illustrative Case

Pediatric Allergy, Immunology, and Pulmonology
Nusa MatijasicIvan Pavic

Abstract

Background: Impaired lung function has been detected in up to 65% of all childhood cancer survivors. It is often caused by exposure to radiation therapy and various chemotherapeutics. The first cytotoxic drug ever identified as a causative agent of lung injury was busulfan, reported in the early 1960s. Signs and symptoms of busulfan lung are nonspecific and it is therefore difficult to differentiate the condition from pulmonary impairment caused by other pulmotoxic agents, infections, pulmonary metastases, graft-versus-host disease, or other noninfectious post-transplant complications involving the lungs. Methods: A case example is provided to illustrate the difficulties in management of busulfan-induced lung injury in children. A retrospective review of cases of busulfan-induced lung injury indexed in PubMed until March 2019 was performed. Inclusion criteria for articles was available in full text in English. Results: Impaired lung function caused by busulfan may become an increasing problem for young survivors. Conclusion: Newly developed dyspnea or subclinical damage detected on pulmonary function tests, indicating primarily restrictive disease, should always arouse suspicion of busulfan-induced lung injury in a child...Continue Reading

References

Jan 1, 1974·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·L N Podoll, S S Winkler
Jan 1, 1966·Annals of Internal Medicine·R V Smalley, R L Wall
Mar 1, 1968·Thorax·B E Heard, R A Cooke
Nov 28, 1970·British Medical Journal·W A Littler, C Ogilvie
May 1, 1981·Journal of Clinical Pathology·A OakhillJ R Mann
Dec 1, 1994·Pediatric Pulmonology·B FaurouxG Tournier
May 17, 2002·Clinical Radiology·Joanne R CleverleyNestor L Müller
Jul 1, 1961·The American Journal of Medicine·H OLINERW DAMESHEK
Apr 6, 2004·Clinics in Chest Medicine·Ulrich CostabelJosune Guzman
Apr 6, 2004·Clinics in Chest Medicine·Andrew H Limper
Aug 28, 2004·Clinics in Chest Medicine·Philippe CamusPascal Foucher
Oct 14, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Matthew UlricksonYi-Bin Chen
Jun 19, 2013·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Hilde Hylland UhlvingKlaus Gottlob Müller
Feb 20, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Philip A ThompsonAshish Bajel
Mar 24, 2016·Pediatric Blood & Cancer·Elizabeth RecordJonathan Popler
May 10, 2017·Clinics in Chest Medicine·Paul LegerFabien Maldonado
Jun 15, 2017·Archives of Pathology & Laboratory Medicine·Ross MillerMaxwell Lawrence Smith
Sep 5, 2017·Pediatric Blood & Cancer·Rahel KastelerUNKNOWN Swiss Pediatric Oncology Group (SPOG)
Mar 20, 2018·Balkan Medical Journal·Güldane Cengiz SevalTaner Demirer

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
bronchoalveolar lavage

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Related Papers

Hoja tisiológica
R J Pintos Fuentes, N Reissenweber
Revista clínica española
A Rodríguez CuarteroJ Peláez Redondo
© 2021 Meta ULC. All rights reserved