Busulfan neurotoxicity and EEG abnormalities: a case report

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
C La MorgiaF Cirignotta

Abstract

A 21-year-old woman with acute lymphoblastic leukemia underwent bone marrow transplantation (BMT). The conditioning regimen consisted of an association of busulfan (BU) and cyclophosphamide (Cy). The day after starting BU, she suffered a generalized tonic-clonic seizure. Electroencephalography (EEG) performed the day after the seizure showed diffuse polyspikes and spike-and-wave discharges. EEG on the following days showed persistent abnormalities (slowing of background activity intermixed with diffuse slow waves and isolated delta and theta bursts). These abnormalities persisted for about 20 days with complete normalization one month after the seizure. We suggest that BU is implicated in these abnormalities and emphasize the importance of EEG recording before and after bone marrow transplantation to disclose BU neurotoxicity.

Citations

Mar 21, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·Gagandeep SinghJosemir W Sander
Nov 26, 2008·Pharmacotherapy·Andrea L EberlyJeannine S McCune
Jan 13, 2010·Acta Ophthalmologica·Alba Lucia TörnquistKristina Teär Fahnehjelm
Nov 10, 2013·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Désirée CaselliUNKNOWN Bone Marrow Transplantation Working Group of the Associazione Italiana Ematologia Oncologia Pediatrica
Aug 3, 2021·Frontiers in Neurology·Zhuo WangSujun Gao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.