PMID: 11903523Mar 21, 2002Paper

Butalbital in the treatment of headache: history, pharmacology, and efficacy

Headache
S Silberstein, Douglas C McCrory

Abstract

Analgesics containing butalbital compounded with aspirin, acetaminophen, and/or caffeine are widely used for the treatment of migraine and tension-type headache. The butalbital-containing compounds are efficacious in placebo-controlled trials among patients with episodic tension-type headaches. Despite their frequent clinical use for migraine, they have not been studied in placebo-controlled trials among patients with migraine. Barbiturates can produce intoxication, hangover, tolerance, dependence, and toxicity. Butalbital can result in intoxication that is clinically indistinguishable from that produced by alcohol. Butalbital-containing analgesics can produce drug-induced headache in addition to tolerance and dependence. Higher doses can produce withdrawal syndromes after discontinuation. Butalbital-containing analgesics may be effective as backup medications or when other medications are ineffective or cannot be used. Because of concerns about overuse, medication-overuse headache, and withdrawal, their use should be limited and carefully monitored.

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Citations

Mar 2, 2002·Current Pain and Headache Reports·William B Young, Hua Chiang Siow
Dec 3, 2010·Current Treatment Options in Neurology·Frederick R Taylor, Robert G Kaniecki
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