Butenafine

Drugs
W McNeely, C M Spencer

Abstract

Butenafine is a new antifungal agent with primary fungicidal activity against dermatophytes such as Trichophyton mentagrophytes, Microsporum canis and Trichophyton rubrum which cause tinea infections. 14C-labelled butenafine (approximately 30 micrograms/g tissue) was found within guinea-pig dorsal skin 24 hours after topical application. Most of the drug was distributed into the epidermis including the horny layer. Small amounts were found in the dermis, probably transported via sebaceous glands and hair follicles. In vitro, the minimum concentration that completely inhibited growth of dermatophytes (MIC) and the minimum fungicidal concentrations (MFC) for butenafine against T. mentagrophytes and M. canis were similar (0.012 to 0.05 mg/L) and were 4 to 130 times lower than those for naftifine, tolnaftate, clotrimazole and bifonazole. It also has greater activity against T. rubrum, M. gypseum and Epidermophyton floccosum when compared with naftifine, tolnaftate and clotrimazole; comparisons with bifonazole against these strains were not available. Assessment after 1 week's treatment in patients with tinea pedis revealed that mycological cure rates were greater in those who received twice-daily butenafine for 1 week or once-daily...Continue Reading

Citations

Mar 15, 2002·American Journal of Clinical Dermatology·Adam I RubinRichard K Scher
Jan 25, 2005·American Journal of Clinical Dermatology·Amber A Kyle, Mark V Dahl
Jun 14, 2005·Bioorganic & Medicinal Chemistry Letters·Lieven MeerpoelRay D Richards
Jul 16, 2008·Expert Opinion on Drug Metabolism & Toxicology·Archana Singal
Oct 19, 2011·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Lin SongLing Wang
Jul 30, 1999·Journal of the American Academy of Dermatology·W K NahmT Rosen
Mar 16, 2001·Expert Opinion on Pharmacotherapy·T A Syed, H I Maibach
Nov 16, 2001·Antimicrobial Agents and Chemotherapy·M P Mingeot-LeclercqR Brasseur

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