PMID: 8585083Sep 1, 1995Paper

Buthus martensi karsch venom: prejunctional adrenergic activity in the rat isolated anococcygeus muscle

Toxicon : Official Journal of the International Society on Toxinology
J GongP Gopalakrishnakone

Abstract

The effect of Buthus martensi Karsch venom (MKV) on adrenergic responses was investigated using the rat isolated anococcygeus muscle (Acm), since several scorpion venoms can cause peripheral sympathetic nerve stimulation with enhanced adrenergic responses. The effects of phentolamine (5 microM), guanethidine (5 microM), tetrodotoxin (2 microM), desipramine (1.5 microM) and reserpine pretreatment in vivo (5 mg/kg s.c. x 24 hr and 5 mg/kg i.p. x 3 hr) on contractile responses of the rat Acm to field stimulation, noradrenaline (3 microM), tyramine (10 microM), crude MKV (2 micrograms/ml), carbachol (3 microM) and potassium chloride (50 mM) were compared. Phentolamine, guanethidine, tetrodotoxin and reserpine pretreatment completely blocked the contractile responses of the Acm to MKV and to field stimulation but desipramine potentiated the responses. The responses to NA were completely blocked by phentolamine, but were potentiated by guanethidine, desipramine and reserpine pretreatment. The contractile responses to tyramine were completely blocked by phentolamine, desipramine and reserpine pretreatment. The low doses (0.1 microgram/ml x 3) of MKV, which did not produce any observable increase in tone of the anococcygeus muscle, pot...Continue Reading

References

Oct 1, 1992·Toxicon : Official Journal of the International Society on Toxinology·E G RowanP Gopalakrishnakone
Sep 1, 1991·Trends in Pharmacological Sciences·U Trendelenburg
Aug 1, 1990·Pharmacology, Biochemistry, and Behavior·E R SmithJ M Davidson
Jan 1, 1990·Cell and Tissue Research·W G DailG Walton
Apr 1, 1972·The American Journal of Physiology·T NarahashiC M Wang
Jul 1, 1972·British Journal of Pharmacology·J S Gillespie
Jan 1, 1980·Annual Review of Pharmacology and Toxicology·W A Catterall
Feb 1, 1994·Toxicon : Official Journal of the International Society on Toxinology·M C GweeP T Wong
Oct 1, 1993·Toxicon : Official Journal of the International Society on Toxinology·M C GweeK S Low

❮ Previous
Next ❯

Citations

Jan 5, 2002·Biochemical Pharmacology·Selvanayagam NirthananMatthew C E Gwee
Oct 8, 2003·Toxicon : Official Journal of the International Society on Toxinology·Cleber E TeixeiraEdson Antunes
Aug 8, 2002·Clinical and Experimental Pharmacology & Physiology·Matthew C E GweeLi-Sam Cheah
Nov 27, 2009·Muscle & Nerve·Mário OshimaYoko Oshima-Franco

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.