PMID: 2125152Dec 3, 1990Paper

Butylated hydroxyanisole (BHA) does not cause forestomach hyperplasia by inhibiting the release of gastric mucus

Toxicology
V LauriaultC J Powell

Abstract

High doses of BHA cause hyperplasia and subsequent neoplasia in the rodent forestomach and can inhibit gastric prostaglandin (PG) synthesis in vitro. This paper examines the hypothesis that BHA induced forestomach hyperplasia occurs in response to a reduction of gastric mucus, with consequent irritation of the forestomach. This could result from inhibition of the formation of the PG's which mediate the synthesis and release of protective mucus. Groups of 10 rats received 0 or 2% BHA in the diet for 1 or 3 weeks and a positive control group was fed a diet containing indomethacin (3.5 mg/kg), a potent inhibitor of PG synthesis. After 1 week BHA caused focal erosion and ulceration of the forestomach consistent with an irritant effect, but 2 weeks later the epithelium was healed, thickened and markedly hyperplastic. Histochemical staining for mucus showed that the development of forestomach hyperplasia was associated with increased amounts of gastric and duodenal mucus and increased numbers of serotonergic-cells in the gastric and duodenal epithelium. In contrast, indomethacin caused a marked reduction in both gastric and Brunner's gland mucus. Neither BHA nor indomethacin exerted an effect on one specific type of mucus (viz: neutr...Continue Reading

References

Apr 1, 1978·The American Journal of Digestive Diseases·J P BoltonM M Cohen
Sep 1, 1988·Biochemical Pharmacology·V L MurtyB L Slomiany
May 1, 1986·Zeitschrift für Gastroenterologie·K F Sewing
Oct 1, 1986·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·F IversonJ Wong
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Feb 1, 1985·Histopathology·F FetissofP Jobard
Feb 1, 1986·Digestive Diseases and Sciences·D E Wilson

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Citations

Apr 1, 1992·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P T Harrison
Jul 20, 2002·Archives of Biochemistry and Biophysics·Donghui MaKandiah Jeyaseelan
Sep 1, 1992·Food Additives and Contaminants·D V Parke, D F Lewis
Dec 1, 1990·Photochemistry and Photobiology·B Z Zmudzka, J Z Beer
Jan 1, 1991·Chemico-biological Interactions·H VerhagenJ C Kleinjans

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