Butyltin compounds in human liver

Environmental Research
Jesper B Nielsen, Jakob Strand

Abstract

Intake of marine food is the main source of butyltin exposure in humans. Health effects following exposure to butyltin compounds are usually in the immune system, but endocrine effects of butyltin from a variety of marine species have been documented. The information on human exposure to butyltin compounds and hepatic deposition is limited. The present study include 18 consecutively sampled human livers analyzed for butyltin compounds. Dibutyltin (DBT) concentrations varied between 0.8 and 28.3 ng/g with a mean concentration of 9.0 ng/g. Significantly lower concentrations of monobutyltin (MBT) were observed, ranging from 0.3 to 4.7 ng/g with a mean value of 1.6 ng/g. Age and DBT/MBT ratio were significantly associated. We suggest that younger men have more recent exposures or have a lower capacity to debutylate DBT than older men and would therefore potentially be more susceptible to butyltin toxicity. Given the interperson variability observed in our limited group of men, we cannot exclude that thresholds for either immunotoxicity or effects on the endocrine system may occur due to exposure to butyltin compounds alone or in combination with other environmental toxicants with similar target organs.

References

Aug 18, 1995·The Science of the Total Environment·P M SarradinM Astruc
May 1, 1993·Food Additives and Contaminants·A H Penninks
Jan 1, 1996·Critical Reviews in Toxicology·K Fent
Feb 20, 1999·Archives of Environmental Health·S UenoT Suzuki
May 3, 2000·Archives of Environmental Contamination and Toxicology·H HarinoS Kawai

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Citations

Nov 4, 2008·Journal of Toxicology and Environmental Health. Part a·V C MoserK D Ehman
Apr 29, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Margaret M WhalenRobert W Luebke
Feb 3, 2012·Environmental Health Perspectives·Wendee Holtcamp
Feb 27, 2015·Journal of Immunotoxicology·Jia ShaoOscar L Volger
Nov 24, 2004·Drug Metabolism Reviews·Klaus E Appel
Jan 15, 2013·Journal of Hazardous Materials·Przemysław BernatJerzy Długoński
Jul 1, 2009·Environmental Toxicology and Pharmacology·Feihuan YanChonggang Wang
Jan 6, 2009·Environmental Toxicology and Pharmacology·Laurin N HollowayMargaret M Whalen
May 22, 2007·Toxicology and Applied Pharmacology·Mélanie GrondinDiana A Averill-Bates
Jun 5, 2014·Environmental Toxicology·Sumonto MitraShashi Khandelwal
Sep 18, 2009·Environmental Toxicology·Zhenghong ZuoChonggang Wang
Sep 17, 2013·Journal of Applied Toxicology : JAT·Lindsay J Celada, Margaret M Whalen
Jan 1, 2005·Environmental Toxicology and Pharmacology·Helena Cristina da Silva de AssisCiro Alberto de Oliveira Ribeiro
Jul 13, 2004·Brain Research. Developmental Brain Research·Scott M JenkinsStanley Barone
Jan 1, 2007·Environmental Toxicology and Pharmacology·Fabiola D GomezMargaret M Whalen
Oct 18, 2005·The Science of the Total Environment·Jakob Strand, Jens A Jacobsen
Jun 9, 2015·Reproductive Toxicology·Priscila L PodratzJones B Graceli
Sep 15, 2004·Environmental Research·Jesper B Nielsen, T H Rasmussen
Jul 28, 2004·Biochimica Et Biophysica Acta·Magdalena JurkiewiczFrancine Denizeau
Dec 4, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Sumonto MitraShashi Khandelwal
Dec 27, 2011·Biochemical and Biophysical Research Communications·Ronald BiemannBernd Fischer
Jan 31, 2018·Journal of Cellular Physiology·James WattJennifer J Schlezinger
Sep 14, 2017·Environmental Science and Pollution Research International·Carolina Falcão XimenesIvanita Stefanon
Apr 30, 2016·Environmental Health Perspectives·Ester López-GallardoEduardo Ruiz-Pesini
Mar 17, 2007·Environmental Toxicology·Fred D DudimahMargaret M Whalen
Apr 10, 2010·Archives of Environmental Contamination and Toxicology·Kurunthachalam KannanShinsuke Tanabe
Jul 18, 2018·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Eduardo MerloJones B Graceli
Mar 30, 2017·Environmental Science and Pollution Research International·Paulina SiewieraPrzemysław Bernat
Feb 6, 2017·Environmental Science and Pollution Research International·Liping FangDongsheng Wang
Jul 11, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xiaozhi QiaoQingshan Li

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