Butyrate and Dietary Soluble Fiber Improve Neuroinflammation Associated With Aging in Mice

Frontiers in Immunology
Stephanie M MattRodney W Johnson

Abstract

Aging results in chronic systemic inflammation that can alter neuroinflammation of the brain. Specifically, microglia shift to a pro-inflammatory phenotype predisposing them to hyperactivation upon stimulation by peripheral immune signals. It is proposed that certain nutrients can delay brain aging by preventing or reversing microglial hyperactivation. Butyrate, a short-chain fatty acid (SCFA) produced primarily by bacterial fermentation of fiber in the colon, has been extensively studied pharmacologically as a histone deacetylase inhibitor and serves as an attractive therapeutic candidate, as butyrate has also been shown to be anti-inflammatory and improve memory in animal models. In this study, we demonstrate that butyrate can attenuate pro-inflammatory cytokine expression in microglia in aged mice. It is still not fully understood, however, if an increase in butyrate-producing bacteria in the gut as a consequence of a diet high in soluble fiber could affect microglial activation during aging. Adult and aged mice were fed either a 1% cellulose (low fiber) or 5% inulin (high fiber) diet for 4 weeks. Findings indicate that mice fed inulin had an altered gut microbiome and increased butyrate, acetate, and total SCFA production. ...Continue Reading

References

Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Jan 28, 2004·British Journal of Pharmacology·Jari HuuskonenAntero Salminen
Sep 29, 2004·JPEN. Journal of Parenteral and Enteral Nutrition·Daniel BunoutCarlos Muñoz
May 28, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J P GodboutR W Johnson
Oct 6, 2005·Applied and Environmental Microbiology·Sandra P van TongerenGjalt W Welling
Feb 22, 2007·The Journal of Nutrition·Marcel Roberfroid
Dec 17, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mark KilgoreGavin Rumbaugh
Jun 24, 2010·Brain, Behavior, and Immunity·Angela M WynneJonathan P Godbout
Mar 16, 2011·Ageing Research Reviews·Elena BiagiPatrizia Brigidi
Apr 12, 2012·Mucosal Immunology·B M Fournier, C A Parkos
Jun 20, 2012·Journal of the Academy of Nutrition and Dietetics·Dana E KingCarol A Lambourne
Jun 30, 2012·Journal of Neuroinflammation·Maria Nikodemova, Jyoti J Watters
Sep 14, 2012·Nature·Valentina Tremaroli, Fredrik Bäckhed
May 1, 2011·Therapeutic Advances in Chronic Disease·Arthur A SimenLisa C Barry
Jan 15, 2014·BMC Bioinformatics·Miron Bartosz Kursa
Dec 19, 2014·Microbiome·Morgan Gi LangilleRobert G Beiko
Jan 16, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Seo-Hyun ChoLi Gan
Jan 27, 2015·The International Journal of Neuropsychopharmacology·Yabin WeiCatharina Lavebratt
Mar 13, 2015·PLoS Pathogens·Philipp KrugerDominik Hartl
Mar 17, 2015·Neuroscience·R M BarrientosS F Maier
Apr 11, 2015·Clinical Epigenetics·Katarzyna Szarc vel SzicWim Vanden Berghe
Apr 29, 2015·Aging Cell·Meaghan J JonesMichael S Kobor
Jul 25, 2015·Annals of Translational Medicine·Wen-Ying WangLan Tan
Nov 4, 2015·Frontiers in Cellular Neuroscience·John R KellyNiall P Hyland
Nov 26, 2015·Current Opinion in Pharmacology·Stephanie M Matt, Rodney W Johnson
Feb 13, 2016·Neuroscience Letters·Megan W BourassaRajiv R Ratan
Nov 1, 2016·Journal of Neurochemistry·Damon J DiSabatoJonathan P Godbout
Mar 26, 2016·Frontiers in Microbiology·Chunlong MuWeiyun Zhu
Oct 25, 2016·Journal of Affective Disorders·Angela C BustamanteMonica Uddin
Aug 25, 2016·Frontiers in Human Neuroscience·Lianne HoeijmakersAniko Korosi
Nov 3, 2016·Proceedings of the National Academy of Sciences of the United States of America·Arti B PatelTheoharis C Theoharides
Dec 9, 2016·Environmental Microbiology·Petra Louis, Harry J Flint
Mar 17, 2017·Scientific Reports·Ephantus J MuturiChang-Hyun Kim

❮ Previous
Next ❯

Citations

Aug 29, 2019·Physiological Reviews·John F CryanTimothy G Dinan
Mar 5, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Shokouh AhmadiHariom Yadav
Dec 8, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Yi SunChristy S Carter
Jun 21, 2019·Circulation Research·Jasenka ZubcevicMohan K Raizada
Oct 3, 2020·Molecular Neurobiology·Gabriela Cruz-Carrillo, Alberto Camacho-Morales
Mar 19, 2019·Exercise and Sport Sciences Reviews·Lucy J MailingJeffrey A Woods
Oct 23, 2019·Signal Transduction and Targeted Therapy·Ziying ZhangYongguang Tao
Aug 25, 2020·Mediators of Inflammation·Kanglan LiBin Zhao
Dec 19, 2019·Frontiers in Immunology·Natalie A ProwAndreas Suhrbier
Apr 9, 2020·Critical Reviews in Food Science and Nutrition·Giovana JamarLuciana Pellegrini Pisani
Apr 29, 2020·Annual Review of Immunology·Justin L McCarvilleJanelle S Ayres
Mar 25, 2019·Frontiers in Immunology·Pushpa PandiyanJochen Huehn
Aug 15, 2020·Frontiers in Nutrition·Florence BaertVeerle Foulon
Feb 6, 2020·Frontiers in Neuroscience·Shin Jie YongWei Ling Lim
Oct 21, 2020·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Canhua XiaoDeborah Bruner
Oct 7, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Ravichandra VemuriKylie Kavanagh
Jan 22, 2021·Journal of Clinical Laboratory Analysis·Alim KeramWenwei Li
Nov 17, 2020·Frontiers in Cellular Neuroscience·Daniel C Shippy, Tyler K Ulland
Sep 1, 2019·Comprehensive Reviews in Food Science and Food Safety·Jiefen CuiJinkai Zheng
Jan 14, 2021·Nutrients·Brigitte M González OlmoRuth M Barrientos
Jan 16, 2021·International Journal of Tryptophan Research : IJTR·Michelle L GarcezGilles J Guillemin
Feb 16, 2021·Frontiers in Nutrition·Amira KohilAnnalisa Terranegra
Feb 7, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Rafael Ochoa-SanchezChristopher F Rose
Oct 11, 2020·Signal Transduction and Targeted Therapy·Ziying ZhangYongguang Tao
Mar 13, 2021·Ageing Research Reviews·Xiao-Hang QianHui-Dong Tang
Mar 23, 2021·Frontiers in Immunology·Leonardo César de Freitas CayresGislane Lelis Vilela de Oliveira
Apr 4, 2021·Journal of Clinical Medicine·Jorge OjedaPía M Vidal
Apr 4, 2021·Microorganisms·Viviana J MancillaMichael S Allen
Jun 27, 2019·Neuroscience Letters·Q LeyrolleA Nadjar
Apr 22, 2021·Minerva Pediatrics·Dhinoth K BangarusamyAnnalisa Terranegra

❮ Previous
Next ❯

Methods Mentioned

BETA
histone acetylation
PCR
electrophoresis
enzyme-linked immunosorbent assay

Software Mentioned

QIIME
Random Forest
PERMANOVA
R RF package
Statistical Analysis System ( SAS
Fluidigm
Boruta
Fluidigm Real - Time PCR Analysis

Related Concepts

Related Feeds

Cell Aging

This feed focuses on cellular aging with emphasis on mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Genetics & Epigenetics of Aging

Dozens of genes are implicated in lifespan, and epigenetic changes during aging affect cell function. This feed focuses on the genetics and epigenetics of aging.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Aging Genetics (Keystone)

This feed focuses on aging epidemiology and genetic, epigenetic, and proteomic aspects underlying aging, as well as aging- associated biomarkers. Here the latest research in this domain.

Brain Aging

Here is the latest research on intrinsic and extrinsic factors, as well as pathways and mechanisms that underlie aging in the central nervous system.