PMID: 2512127Nov 20, 1989Paper

Butyrobetaine availability in liver is a regulatory factor for carnitine biosynthesis in rat. Flux through butyrobetaine hydroxylase in fasting state

European Journal of Biochemistry
A Sandor, C L Hoppel

Abstract

Urinary excretion of total carnitine in 48-h fasted rats dropped to 0.30 +/- 0.01 mumol/day from 2.23 +/- 0.4 mumol/day found in fed, control animals (mean +/- SEM). Despite this marked retention, the total carnitine content of the whole body remained constant, about 83 mumol, predicting a slow-down in biosynthesis. The conversion of butyrobetaine into carnitine takes place only in the liver in rats. 48 h of starvation caused a decrease in the liver butyrobetaine level from 11.6 +/- 1.19 nmol/g to 9.30 +/- 1.19 nmol/g, which in whole livers corresponds to a decrease from 138 nmol to 61.3 nmol. The conversion rate of butyrobetaine into carnitine was studied with radiolabelled butyrobetaine. 30 min after injection of [3H]butyrobetaine the carnitine pool in the liver of fasted rats was labelled to about the same extent as that in fed rats, but from a butyrobetaine pool with higher specific radioactivity. Therefore, the conversion rate of butyrobetaine into carnitine was reduced. The newly formed carnitine found in the whole body of fasted rats was estimated to be 59% of controls. We conclude that the biosynthesis of carnitine in fasted rats slows down, for which a decreased availability of butyrobetaine in the liver is responsible...Continue Reading

References

Nov 2, 1976·Biochimica Et Biophysica Acta·R Z Christiansen, J Bremer
Jan 9, 1987·Biochimica Et Biophysica Acta·G KispalA Sandor
Aug 15, 1988·Clinica Chimica Acta; International Journal of Clinical Chemistry·A SandorC L Hoppel
Jun 14, 1985·Biochimica Et Biophysica Acta·A SandorI Alkonyi
May 24, 1974·Biochimica Et Biophysica Acta·T Bohmer
Jun 28, 1974·Clinica Chimica Acta; International Journal of Clinical Chemistry·G CederbladK Lundholm
May 1, 1983·The Journal of Nutrition·A T Davis, C L Hoppel

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Citations

Jan 23, 2002·The Biochemical Journal·Frédéric M Vaz, Ronald J A Wanders
May 29, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S KrähenbühlC L Hoppel
Aug 8, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S BerardiS Krahenbühl
Jun 6, 2000·Biochimica Et Biophysica Acta·G M FischerA Sandor
Dec 3, 2016·Biological & Pharmaceutical Bulletin·Yoshiyuki KuboKen-Ichi Hosoya
May 8, 1991·Biochimica Et Biophysica Acta·A Sandor
Jun 9, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Saori IkedaKen-ichi Hosoya

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