Butyrylated starch increases large bowel butyrate levels and lowers colonic smooth muscle contractility in rats

Nutrition Research
Balázs H BajkaGlen S Patten

Abstract

The short-chain fatty acids acetate, propionate, and butyrate are produced by colonic bacterial fermentation of carbohydrates. Butyrate is important in the regulation of the colonocyte cell cycle and gut motility and may also reduce the risk of large bowel cancer. We have shown that dietary butyrylated starch can deliver butyrate to the large bowel in a sustained manner. We hypothesized that ingestion of butyrylated starch increases large bowel butyrate levels and decreases colonic contractility. Groups of male Sprague-Dawley rats (n = 8) were fed AIN-93G-based diet containing a highly digestible low-amylose maize starch (LAMS) control or 5% or 10% butyrylated LAMS (LAMSB) for 10 days. We found that cecal but not colonic tissue weight as well as cecal and distal colonic digesta weights and fecal output were higher in LAMSB fed rats. Butyrylated LAMS lowered digesta pH throughout the large bowel. Cecal, proximal, and distal colonic butyrate pools and portal venous butyrate concentrations were higher in rats fed LAMSB. Electrically stimulated and receptor-dependent carbachol and prostaglandin E(2)-induced isotonic contractions were lower in isolated intact sections of proximal colon (P < .05) but not the terminal ileum after 10% ...Continue Reading

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Citations

Jun 23, 2011·Clinical and Experimental Gastroenterology·Glen S PattenMahinda Y Abeywardena
Sep 16, 2015·Age·Michael J KeenanRoy J Martin
Apr 2, 2015·Journal of Gastroenterology and Hepatology·Tadashi ShimoyamaYoshihiro Fukuda
Jan 27, 2015·Digestive Diseases and Sciences·Glen S PattenMichael A Conlon
Oct 19, 2011·Food & Function·Mary Ann AugustinLuz Sanguansri
Oct 14, 2011·Journal of Clinical Gastroenterology·George T Macfarlane, Sandra Macfarlane
Dec 3, 2016·The Journal of Pharmacology and Experimental Therapeutics·Glen Stephen Patten, Mahinda Yapa Abeywardena
Sep 24, 2011·The American Journal of Clinical Nutrition·Julie M ClarkeLynne Cobiac
Nov 12, 2020·Drug Design, Development and Therapy·FangTing YuanHeSheng Luo
Feb 27, 2021·The International Journal of Biochemistry & Cell Biology·Julie E DalzielWayne Young

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