PMID: 8551790Jan 1, 1996

Bypass conduit vessel wall biology substantially influences downstream myocardial contractile response to injury from ischemia and reperfusion

The Journal of Thoracic and Cardiovascular Surgery
B L RobinsonJ J Morris

Abstract

Coronary vascular intraluminal release of endogenous endothelium-derived substances, such as prostacyclin, may affect downstream cardiac myocyte contractile function. With a "chronic" canine model of endothelialized and deendothelialized internal thoracic artery coronary grafts, we tested the hypothesis that higher basal release of endothelium-derived prostacyclin in internal thoracic artery bypass conduit effluent accelerates functional recovery of postischemic stunned myocardium in the intact circulation. Eleven dogs underwent left internal thoracic artery-left circumflex artery bypass, and the proximal circumflex artery was then ligated. Internal thoracic artery conduit endothelium was denuded by balloon catheter in five dogs before grafting and left intact in six dogs. After 7 days, awake dogs were studied to measure myocardial segment length in the circumflex region with ultrasonic dimension transducers, left ventricular pressure with micromanometers, and circumflex artery flow with an ultrasonic flow probe. Regional contractile function was quantified by the area beneath the linear preload recruitable stroke work relationship at baseline and at intervals after a 15-minute circumflex graft occlusion followed by 3 hours of ...Continue Reading

References

Feb 1, 1988·Circulation Research·N E FarberG J Gross
Aug 25, 1988·The New England Journal of Medicine·T F LüscherE Weber
Apr 1, 1988·The Annals of Thoracic Surgery·P T AarnioS P Mattila
Aug 1, 1983·Journal of the American College of Cardiology·J A Melin, L C Becker
Jan 1, 1993·Annual Review of Pharmacology and Toxicology·A M Lefer, D J Lefer

Related Concepts

Coronary Circulation
Canis familiaris
Endothelium, Vascular
Hemodynamics
Internal Mammary-Coronary Artery Anastomosis
Scanning Electron Microscopy
Myocardial Contraction
Flolan
Thoracic Arteries
Myocardial Reperfusion Injury

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