"Bystander" damage of host muscle caused by implantation of MHC-compatible myogenic cells

Journal of the Neurological Sciences
A Wernig, A Irintchev

Abstract

Transplantation of normal myoblasts has been considered a potential therapy for muscle dystrophies. While survival of implanted cells has been described in animal experiments and in human trials, functional effects remained unclear. Here we report on survival of progenors of implanted C2nlsBAG cells in regenerating muscles but irreversible net loss in muscle tissue and contractile force. This is caused by immune rejection of implanted myoblasts despite MHC-compatibility and "bystander" damage of host muscle tissue.

References

Jan 1, 1979·Immunological Reviews·J A Ledbetter, L A Herzenberg
Sep 1, 1992·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·J E Morgan, T A Partridge
Dec 1, 1991·Journal of Neurocytology·A WernigA Starzinski-Powitz
Jan 1, 1991·Neuromuscular Disorders : NMD·D J WattT A Partridge
Apr 1, 1995·Journal of Neurocytology·A IrintchevA Wernig
Apr 1, 1994·Developmental Dynamics : an Official Publication of the American Association of Anatomists·A IrintchevA Wernig

❮ Previous
Next ❯

Citations

Jul 1, 1996·Muscle & Nerve·Y FanM Grounds
Apr 1, 1995·Journal of Neurocytology·A IrintchevA Wernig
Feb 24, 2005·Cell and Tissue Research·Elen H MiyabaraAnselmo S Moriscot
Mar 1, 1997·Neuromuscular Disorders : NMD·A IrintchevA Wernig
Dec 2, 2004·Expert Opinion on Biological Therapy·Daniel Skuk
Jan 6, 2011·Expert Opinion on Biological Therapy·Daniel Skuk, Jacques P Tremblay
Feb 9, 2000·FEBS Letters·J W BartschH Jockusch
Nov 28, 2018·Journal of Neuropathology and Experimental Neurology·Daniel Skuk, Jacques P Tremblay
Nov 18, 2005·American Journal of Physiology. Cell Physiology·Elen H MiyabaraRuben Mestril
Apr 11, 2012·Journal of Neuropathology and Experimental Neurology·Daniel Skuk
Jul 19, 2003·Journal of Cardiac Surgery·Eugene K W SimKhawaja H Haider
Oct 19, 2000·Cell Transplantation·C N PagelT A Partridge
Jul 18, 2001·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·R A Collins, M D Grounds

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.