Bystander injury of host lymphoid tissue during murine graft-verus-host disease is mediated by nitric oxide

Transplantation
R A HoffmanR L Simmons

Abstract

The suppressed lymphocyte proliferative responses characteristic of graft-versus-host disease (GVHD) are due, in part, to production of nitric oxide (NO). In order to more fully elucidate the role of NO during GVHD, an NO synthesis inhibitor, aminoguanidine (AG), was administered to unirradiated (C57BL/6J X DBA/2J)F1 mice injected with 5 X 10(7) C57BL/6J splenocytes. Administration of AG resulTed in abrogation of the elevation in serum NO2- + NO3- levels characteristic of GVHD. A significantly increased percentage of splenocytes of host phenotype (H2b/d, B220+, and THY1.2+) and a significantly higher hematocrit value were detected in GVHD animals receiving AG therapy. Additionally, the Con A-induced proliferative response of splenocytes obtained from GVHD mice receiving AG therapy was increased compared with the responses of splenocytes from animals that did not receive AG therapy. Parameters not affected by AG therapy included NO synthesis by recovered peritoneal macrophages, donor antihost cytolytic activity in splenocyte populations, serum GM-CSF levels and long-term engraftment of donor cells. These data indicate that NO may play a role in the destruction of both lymphoid and erythroid host tissue as well as the reduced lym...Continue Reading

References

Aug 1, 1992·The Journal of Clinical Investigation·J M LangrehrR A Hoffman
Aug 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S PicardJ L Witztum
Aug 1, 1992·European Journal of Immunology·P GarsideA M Mowat
Mar 7, 1991·The New England Journal of Medicine·J L Ferrara, H J Deeg
Apr 1, 1991·The Journal of Surgical Research·J E Albina, W L Henry
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J S BeckmanB A Freeman
Nov 30, 1988·Biochemical and Biophysical Research Communications·J B HibbsE M Rachlin
Oct 1, 1982·Analytical Biochemistry·L C GreenS R Tannenbaum
Jan 1, 1995·The Journal of Experimental Medicine·N K WorrallT B Ferguson
Mar 16, 1993·European Journal of Pharmacology·T P MiskoM G Currie
Aug 1, 1993·The Journal of Experimental Medicine·N McCartney-FrancisS M Wahl
Oct 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J A CorbettE R Unanue
Sep 27, 1994·Proceedings of the National Academy of Sciences of the United States of America·R BucalaH Vlassara
Jun 1, 1960·British Journal of Pharmacology and Chemotherapy·S E LINDELLH WESTLING

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Citations

Jun 18, 1999·Transplantation Proceedings·F H BachC Ferran
Feb 3, 1999·Annals of the New York Academy of Sciences·B VanhoveJ P Soulillou
Sep 18, 2012·Transplant Immunology·Eun-Kee SongChang-Yeol Yim
Jul 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·David HongoDonald A Cohen

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